Effect of Crystallinity on the Percutaneous Absorption of Corticosteroid. I. Determination of the Degree of Crystallinity of Hydrocortisone Acetate in Ground Mixtures with Crystalline Cellulose
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概要
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The effect of the crystallinity of a topically applied drug on its percutaneous absorption was investigated with hydrocortisone acetate as a model drug. To decrease the degree of crystallinity, the drug was ground with crystalline cellulose. The X-ray diffraction method for determining the degree of crystallinity was shown to be valid in the range of amorphous cellulose ratio of 0 to ca. 50% by using simple mixtures of glutathione and amorphous cellulose. Thus, the dissolution rate of hydrocortisone acetate was confirmed to increase quantitatively with decreasing crystallinity.
- 公益社団法人日本薬学会の論文
- 1985-02-25
著者
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広田 貞雄
Pharmaceutical Formulation Research Center Research Institute Daiichi Pharmaceutical Co. Ltd. :(pres
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森田 正美
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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絹野 浩二
Pharmaceutical Formulation Research Center
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片岡 捷夫
Pharmaceutical Formulation Research Center, Research Institute, Daiichi Seiyaku Co., Ltd.,
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森田 正美
Pharmaceutical Formulation Research Center, Research Institute, Daiichi Seiyaku Co., Ltd.
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絹野 浩二
Pharmaceutical Formulation Research Center:research Institute Daiichi Seiyaku Co. Ltd.
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片岡 捷夫
Pharmaceutical Formulation Research Center Research Institute Daiichi Seiyaku Co. Ltd.
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