Lipid A and Related Compounds. XXXIII.Synthesis and Structure-Activity Relationships of N-Acylated L-Serine or L-Threonine-Containing D-Glucosamine Derivatives as Mimics of Lipid A Disaccharide

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概要

• 論文の詳細を見る

• Four novel N-acylated L-serine or L-threonine-containing non-phosphorylated D-glucosamine derivatives structurally corresponding to the lipid A disaccharide backbone were synthesized. Compounds 2,3 and 4 exhibited potent mitogenic activity. Among the threonine-linked lipid A analogs (1-3), serine-lipid A analogs (4-6) and homoserine-linked lipid A analogs (7-9), the serine compounds (4,6) showed the most potent mitogenic activity.

• 公益社団法人日本薬学会の論文
• 1997-06-15

著者

• 阿知波 一雄

  静岡県立大学薬学部

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  静岡県大薬

• 阿知波 一雄

  東大・薬

• 池田 潔

  School Of Pharmaceutical Sciences University Of Shizuoka

• 池田 潔

  Tanabe Seiyaku Co. Ltd. Saitama Jpn

• ACHIWA Kazuo

  School of Pharmaceutical Sciences, University of Shizuoka

• IKEDA Kiyoshi

  School of Pharmaceutical Sciences, University of Shizuoka

• MIYAJIMA Keisuke

  School of Pharmaceutical Sciences, University of Shizuoka

• GOMI Noriaki

  School of Pharmaceutical Sciences, University of Shizuoka

• Gomi Noriaki

  School Of Pharmaceutical Sciences University Of Shizuoka

• Achiwa Kazuo

  School Of Pharmaceutical Sciences University Of Shizuoka

• Achiwa Kazuo

  School Of Pharmaceutical Sciences(laboratory Of Medicinal Chemistry)

• Ikeda Kiyoshi

  Department Of Biochemistry Osaka University Of Pharmaceutical Sciences

• 池田 かおり

  Developmental Research Laboratories Shionogi & Co. Ltd.

• Ikeda Kaori

  Developmental Research Laboratories Shionogi & Co. Ltd.

• Miyajima K

  Department Of Otolaryngology Tokyo Women's Medical University Daini Hospital

• Ikeda Kiyoshi

  School Of Information Science Japan Advanced Institute Of Science And

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