Efficient Asymmetric Hydrogenation of β- and γ-Amino Ketone Derivatives Leading to Practical Synthesis of Fluoxetine and Eprozinol
スポンサーリンク
概要
- 論文の詳細を見る
N-(Methylcarbamoyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine (MCCPM)- and N-(tert-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine (BCPM)-rhodium(I) complexes werer efficient catalysts for asymmetric hydrogenations of β- and γ-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient syntheses of fluoxetine and eprozinol from intermediate optically active amino alcohols.
- 公益社団法人日本薬学会の論文
- 1995-05-15
著者
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阿知波 一雄
静岡県立大学薬学部
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阿知波 一雄
School of Pharmaceutical Sciences, University of Shizuoka
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阿知波 一雄
静岡県大薬
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桜庭 俊司
School of Pharmaceutical Sciences, University of Shizuoka
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桜庭 俊司
School Of Pharmaceutical Sciences University Of Shizuoka
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Sakuraba Shunji
School Of Pharmaceutical Sciences University Of Shizuoka
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