108(P40) 植物培養細胞を用いるポドフィロトキシン誘導体等の合成研究(ポスター発表の部)
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概要
- 論文の詳細を見る
In recent years, much attention has been paid to the ability of cultured plant cells to transform not only secondary metabolites, but also organic foreign substrates. Therefore, we have studied in the feasibility of using plant cell cultures as the reagents of organic synthesis. In this symposium, we report the synthesis of biologically active com-pounds by using plant cell cultures (N. tabacum, D. carota, C. roseus, P. peltatum) as follows (1) Synthesis of optically active α-phenylpyridylmethanols as organic foreign substrates i) enantioselective reduction of ketone ii) asymmetric hydrolysis of the acetates iii) optically active alcohols production from the corresponding racemates (deracemization of racemates) (2) The efficient synthesis of podophyllotoxin derivatives as starting materials in the clinical anti-cancer drug, Etoposide
- 天然有機化合物討論会の論文
- 1996-09-02
著者
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阿知波 一雄
静岡県立大学薬学部
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阿知波 一雄
School of Pharmaceutical Sciences, University of Shizuoka
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阿知波 一雄
静岡県大薬
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阿知波 一雄
東大・薬
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竹元 万寿美
静岡県大薬
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山本 裕一
静岡県大薬
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Kutney James
ブリティッシュコロンビア大
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Stoynov Nikolay
ブリティッシュコロンビア大
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Achiwa Kazuo
School Of Pharmaceutical Sciences(laboratory Of Medicinal Chemistry)
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Takemoto Masumi
School Of Pharmaceutical Sciences(laboratory Of Medicinal Chemistry)
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