LIPASE-CATALYZED ENANTIOSYNTHESIS OF (R)- AND (S)-2-[BENZYL(PHENYL)AMINO]ETHYL 5-(5,5-DIMETHYL-2-OXO-1,3,2-DIOXAPHOSPHORINAN-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3-PYRIDINECARBOXYLATE (NZ 105)

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概要

• 論文の詳細を見る

• Homochiral 4-Aryl-1,4-dihydropyridine-5-phosphate (NZ 105) was synthesized from the racemic materials. The enantioselective hydrolysis by lipase catalyst was smoothly proceeded and optically active carboxylic acid was converted into optically active medicine.

• 社団法人日本薬学会の論文
• 1995-07-15

著者

• 阿知波 一雄

  静岡県立大学薬学部

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  静岡県大薬

• 阿知波 一雄

  東大・薬

• 海老池 啓達

  School Of Pharmaceutical Sciences University Of Shizuoka

• 山嵜 行由

  School of Pharmaceutical Sciences, University of Shizuoka

• Yamazaki Yohko

  微生物化学研究会微生物化学研究センター沼津創薬医科学研究所

• 山嵜 行由

  School Of Pharmaceutical Sciences University Of Shizuoka

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