Convenient Syntheses of Optically Active β-Lactams by Enzymatic Resolution

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概要

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• Optically active β-lactams were synthesized by lipase-catalyzed kinetic resolution using the enantioselective hydrolysis of N-acyloxymethyl β-lactams (3) in an organic solvent and the transesterification of N-hydroxymethyl β-lactams (2) with vinyl acetate. A variety of highly optically pure β-lactams (2 and 3) possessing some substituents at the 3,4,or both positions were obtained and the optically active N-hydroxymethyl β-lactams prepared were converted into useful N-unsubstituted ones without racemization.

• 社団法人日本薬学会の論文
• 1993-11-15

著者

• 阿知波 一雄

  静岡県立大学薬学部

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  静岡県大薬

• 塩沢 竜志

  静岡県立大学

• 塩沢 竜志

  Graduate School of Nutritional & Environmental Sciences, University of Shizuoka

• 寺尾 良保

  Graduate School of Nutritional & Environmental Sciences, University of Shizuoka

• 永井 葉月

  Graduate School of Nutritional and Environmental Sciences University of Shizuoka

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