LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF 4-ALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES : SYNTHESIS OF (+)- AND (-)-METHYL 2-(PHENYLTHIO)ETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE (PCA 4248)
スポンサーリンク
概要
- 論文の詳細を見る
Asymmetric synthesis of (+)- and (-)-PCA 4248 (PAF antagonist) was achieved using lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The enzymatic reaction proceeded under the mild conditions in an organic solvent.
- 社団法人日本薬学会の論文
- 1992-04-25
著者
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阿知波 一雄
School of Pharmaceutical Sciences, University of Shizuoka
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海老池 啓達
School Of Pharmaceutical Sciences University Of Shizuoka
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丸山 香
School of Pharmaceutical Sciences, University of Shizuoka
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丸山 香
School Of Pharmaceutical Sciences University Of Shizuoka
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