有機溶媒中での酵素触媒不斉反応の設計と光学活性医薬品合成への応用
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概要
- 論文の詳細を見る
New strategy of lipase-catalyzed asymmetric reactions is described. Chiral 2-<I>O</I>-substituted glycerols, 2-substituted 1, 3-propanediols and 1, 4-diols were obtained in high optical yields by the asymmetric transesterification using activated esters as acyl donors. Facile process for the kinetic resolution of racemic alcohols was developed by the lipase-catalyzed esterification with acid anhydride. And chiral 1, 4-dihydropyridines and barbiturates were obtained in high optical yields by the lipase-catalyzed hydrolysis of their acyloxymethyl groups. Chiral medicines were synthesized from optically active compounds obtained by these lipase-catalayzed asymmetric reactions.
- 社団法人 有機合成化学協会の論文
著者
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阿知波 一雄
静岡県立大学薬学部
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海老池 啓達
School Of Pharmaceutical Sciences University Of Shizuoka
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村田 正和
School Of Pharmaceutical Sciences University Of Shizuoka
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村田 正和
静岡県立大学薬学部
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海老池 啓達
静岡県立大学薬学部
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