Lipase-Catalyzed Enantioselective Synthesis of Optically Active Mephobarbital, Hexobarbital and Febarbamate
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概要
- 論文の詳細を見る
Chiral 5,5-disubstituted N-acyloxymethylbarbiturates have been obtained in 40-99% optical yields by lipase-catalyzed hydrolyses of 5,5-disubstituted N, N'-bisacyloxymethylbarbiturates in H_2O-saturated diisopropyl ether. These chiral barbiturates were readily converted into chiral drugs, mephobarbital, hexobarbital and febarbamate.
- 公益社団法人日本薬学会の論文
- 1992-10-25
著者
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阿知波 一雄
School of Pharmaceutical Sciences, University of Shizuoka
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内田 裕
School Of Pharmaceutical Sciences University Of Shizuoka
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村田 正和
School Of Pharmaceutical Sciences University Of Shizuoka
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