Antibody-Producing Effects in Mice by Synthetic Immunoactive Lipopeptides with the Conjugated Amino Acid Sequence of gp120 in Human Immunodeficiency Virus

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概要

• 論文の詳細を見る

• To induce peptide-specific antibodies in mice, as a model for vaccination against human immunodeficiency virus (HIV), lipopeptide analogs conjugated with three repeating units (KAB-112; designated as gp120-peptide) of a part (Gly-Pro-Gly-Arg-Ala-Phe) of the amino acid sequences of the V3 loop region in gp120 of HIV were synthesized. The mitogenicity, production of nitric oxide (NO) and induction of peptide-specific antibodies in mice by synthetic lipopeptides were examined. Compounds, KAB-8 (diacylglycerol-tetrapeptide having a part of the amino acid sequence in Escherichia coli), KAB-116 (diacyglycerol-cysteine), KAB-117 (diacylglycerol with gp120-peptide) and KAB-121 (KAB-8 with gp120-peptide) were capable of increasing significantly the incorporation of [^3H]thymidine into splenocytes of C3H/He mice at concentrations ranging from 12.5 to 100 μM, but KAB-112 (gp120-peptide) and KAB-115 (monoacylglycerol with gp120-peptide) did not show such activity. The compounds, KAB-8,KAB-117 and 121,exhibited NO production in murine macrophages. When 50 nmol of these compounds was administered intraperitoneally into BALB/c mice on days 0,16 and 46,the peptide-specific antibody titers in their sera produced by each compound were determined with ELISA. The sera of KAB-117 and KAB-121,which were obtained on days 14,30,42,57 and 70,had a higher titer than that of KAB-112 and KAB-115,suggesting that the diacylglycerol derivatives enhance the production of the peptide-specific antibodies.

• 公益社団法人日本薬学会の論文
• 1996-10-15

著者

• 阿知波 一雄

  静岡県立大学薬学部

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  静岡県大薬

• 阿知波 一雄

  東大・薬

• YANAGIHARA Yasutake

  Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka

• Yanagihara Y

  Univ. Shizuoka Shizuoka Jpn

• Ryoyama Kazuo

  Cancer Research Institute Kanazawa University

• Achiwa Kazuo

  School Of Pharmaceutical Sciences(laboratory Of Medicinal Chemistry)

• SHIMIZU Tadayori

  University of Shizuoka, School of Pharmaceutical Sciences

• IWAMOTO Yoshihisa

  University of Shizuoka, School of Pharmaceutical Sciences

• YANAGIHARA Yasutake

  University of Shizuoka, School of Pharmaceutical Sciences

• MARUYAMA Yasufumi

  University of Shizuoka, School of Pharmaceutical Sciences

• ACHIWA Kazuo

  University of Shizuoka, School of Pharmaceutical Sciences

• Shimizu Tadayori

  University Of Shizuoka School Of Pharmaceutical Sciences

• Maruyama Yasufumi

  University Of Shizuoka School Of Pharmaceutical Sciences

• Iwamoto Y

  University Of Shizuoka School Of Pharmaceutical Sciences

• Shimizu Takao

  Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technol

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