Singlet Oxygen Production and Photobiological Effects of Pinacyanol Chloride on Yeast Saccharomyces cerevisiae

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概要

• 論文の詳細を見る

• Photobiological activities of pinacyanol chloride (PC), which is known as a non-intercalating dye, were investigated. Irradiation of PC-sensitized yeast cells in the dark brought about marked decrease of survival and induction of "petites" which are respiration-deficient mutants caused by partial loss of mitochondrial deoxyribonucleic acid. Nuclear mutation represented by reversion from Try-to Trp^+ was also induced by photodynamic action of PC. This fact suggested photoactive dyes are not necessarily intercalated for inducing mitochondrial and nuclear mutation. Singlet oxygen production was determined in the photoirradiated PC solution by electron spin resonance spectrometry. Photobiological effects of PC might be brought about mainly by a type II photodynamic mechanism.

著者

• MASUZAWA Toshiyuki

  Department of Microbiology and COE Program in the 21st Century, University of Shizuoka School of Pha

• YANAGIHARA Yasutake

  Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka

• Yanagihara Y

  Univ. Shizuoka Shizuoka Jpn

• IWAMOTO Yoshihisa

  Department of Microbiology, School of Pharmaceutical Science, University of Shizuoka

• TSUCHIYA Masahiko

  Department of Physical Chemistry, Faculty of Engineering, Yokohama National University

• Morita Tamotsu

  Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka

• SHIMIZU Tadayori

  Department of Microviology, School of Pharmaceutical Sciences, University of Shizuoka

• Masuzawa T

  Univ. Shizuoka Shizuoka Jpn

• Masuzawa Toshiyuki

  Department Of Microbiology And Coe Program In The 21st Century University Of Shizuoka School Of Phar

• MURAKAMI Kyouko

  Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka

• DANNO Masakazu

  Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka

• SHIMIZU Tadayori

  University of Shizuoka, School of Pharmaceutical Sciences

• IWAMOTO Yoshihisa

  University of Shizuoka, School of Pharmaceutical Sciences

• Shimizu Tadayori

  University Of Shizuoka School Of Pharmaceutical Sciences

• Iwamoto Y

  University Of Shizuoka School Of Pharmaceutical Sciences

• Iwamoto Yoshihisa

  Department Of Microbiology School Of Pharmaceutical Science University Of Shizuoka

• Murakami Kyouko

  Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka

• Danno Masakazu

  Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka

• Yanagihara Yasutake

  Department Of Medical Microbiology College Of Public Health University Of The Philippines

• Shimizu Takao

  Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technol

• Tsuchiya Masahiko

  Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka

• Tsuchiya Masahiko

  Department Of Industrial Chemistry Faculty Of Engineering The University Of Tokyo

• Masuzawa Toshiyuki

  Shizuoka Inst. Environment And Hygiene Shizuoka

• SHIMIZU Tadayori

  Department of Microbiology, Jichi Medical School

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