Cross-Antigenicity between Penams and Cephems by Intradermal Skin Test and Leucocyte Migration Test in Guinea Pigs

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概要

• 論文の詳細を見る

• The delayed-type hypersensitivity (DTH) reactions for penams or cephems of beta-lactam antibiotics were investigated by intrademal skin test and leucocyte migration test (LMT) in guinea pigs. The animals were immunized with ampicillin (ABPC) or cephalexin (CEX) using Freund's complete adjuvant. The cross-reactivities among ABPC, penicillin G (PCG) and cloxacillin as penam and CEX, cephalothin (CET) and cephalosporin C (CEPC) as cephem and phenylglycine (PhGly), which is the amino acyl side chain of ABPC and CEX, were examined. By intradermal reaction, ABPC-sensitized animals showed a cross-reaction with CEX, PCG and CET, but CEX-sensitized animals did not cause cross-reaction with ABPC. The CEX-sensitized group exhibited slight cross-reactions to CET and PhGly. PhGly exhibited low immunogenicity only in maximzation test of guinea pig. The above results indicate that there is the difference in cross-reactivity between penams and cephems in skin test. In LMT, all the ABPC-sensitized animals reacted with ABPC and showed cross-reactions with all drugs tested. The CEX-sensitized group reacted with 4 out of 7 animals with CEX and exhibited cross-reactivities to ABPC, PCG, CET, CEPC and PhGly. The cross-reactivity between intradermal skin reaction and LMT elicited some different results.

• 公益社団法人日本薬学会の論文

著者

• MASUZAWA Toshiyuki

  Department of Microbiology and COE Program in the 21st Century, University of Shizuoka School of Pha

• YANAGIHARA Yasutake

  Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka

• Yanagihara Y

  Univ. Shizuoka Shizuoka Jpn

• Nagakura Naoki

  Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka

• SHIMIZU Tadayori

  Department of Microviology, School of Pharmaceutical Sciences, University of Shizuoka

• Masuzawa T

  Univ. Shizuoka Shizuoka Jpn

• Masuzawa Toshiyuki

  Department Of Microbiology And Coe Program In The 21st Century University Of Shizuoka School Of Phar

• KOBAYASHI Tadamasa

  Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka

• SHIMIZU Tadayori

  University of Shizuoka, School of Pharmaceutical Sciences

• Shimizu Tadayori

  University Of Shizuoka School Of Pharmaceutical Sciences

• Kobayashi T

  Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka

• Yanagihara Yasutake

  Department Of Medical Microbiology College Of Public Health University Of The Philippines

• Shimizu Takao

  Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technol

• Masuzawa Toshiyuki

  Shizuoka Inst. Environment And Hygiene Shizuoka

• SHIMIZU Tadayori

  Department of Microbiology, Jichi Medical School

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