SYNTHESIS OF AXIALLY DISSYMMETRIC BIPHENYLBISPHOSPHINE LIGANDS, BIMOPS AND ASYMMETRIC HYDROGENATIONS OF β-KETO ESTER AND α, β-UNSATURATED CARBOXYLIC ACID CATALYZED BY THEIR RUTHENIUM (II) COMPLEXES

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概要

• 論文の詳細を見る

• Axially dissymmetric biphenylbisphosphine ligands, BIMOP (1a) and p-MeO-BIMOP (1b) have been newly designed and prepared. The ruthenium (II) complexes of (R)-1a and 1b proved to be excellent catalysts in asymmetric hydrogenations of methyl 3-oxobutanoate and tiglic acid affording (R)-methyl 3-hydroxybutanoate of 95-99 % ee and (R)-2-methylbutyric acid of 86-91 % ee, respectively.

• 公益社団法人日本薬学会の論文
• 1991-04-25

著者

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 山本 菜穂子

  School Of Pharmaceutical Sciences University Of Shizuoka

• 村田 正尚

  School of Pharmaceutical Sciences, University of Shizuoka

• 森本 俊明

  School Of Pharmaceutical Sciences University

• 村田 正尚

  School Of Pharmaceutical Sciences University Of Shizuoka

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