DESIGN OF METHOXY-SUBSTITUTED BPPM ANALOGUES AND THEIR APPLICATION TO THE ASYMMETRIC SYNTHESIS OF N__-ACETYLPHENYLALANINE

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概要

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• We describe the preparation of methoxy-substituted BPPM ((2S__-, 4S__-)-N__--(<tert>___--butoxycarbonyl)-4-(diphenylphosphino)-2-[(diphenylphosphino)-methyl]pyrrolidine) analogues for highly effective asymmetric hydrogenation of (Z__-)-2-acetamidocinnamic acid. o__--Methoxy-BPPM-Rh^+ gave a very high optical yield (98% enantiomeric excess (ee), (R__-)) and p__-methoxy-BPPM-Rh^+ was very actively catalytic ([Subst.]/[Rh]=10^4). On the bases of these results and our "respective control concept, " we developed a highly effective chiral ligand (5) for asymmetric synthesis of N__-acetylphenylalanine.

• 公益社団法人日本薬学会の論文
• 1988-08-25

著者

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 高橋 寿

  School Of Pharmaceutical Sciences University Of Shizuoka

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