Asymmetric Synthesis of (R)-Nilvadipine and (S)-NB 818 via Regioselective Bromination of Chiral 1,4-Dihydropyridines as a Key Step and Enzymatic Resolution of Racemic 2-Hydroxymethyl-1,4-dihydropyridine Derivatives

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概要

• 論文の詳細を見る

• Optically active 2-hydroxymethyl-1,4-dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2-hydroxymethyl-1,4-dihydropyridine. On the other hand, chiral 1,4-dihydropyridines obtained from prochiral substrates have been converted into (S)-NB 818 and (R)-nilvadipine via regioselective bromination of methyl groups under mild conditions.

• 公益社団法人日本薬学会の論文
• 1997-05-15

著者

• 阿知波 一雄

  静岡県立大学薬学部

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  静岡県大薬

• 阿知波 一雄

  東大・薬

• Maruyama K

  帝京大学 薬 薬剤

• Yamazaki Yohko

  微生物化学研究会微生物化学研究センター沼津創薬医科学研究所

• ACHIWA Kazuo

  School of Pharmaceutical Sciences, University of Shizuoka

• Yamazaki Yoko

  Numazu Bio-medical Research Institute Microbial Chemistry Research Center

• Achiwa Kazuo

  School Of Pharmaceutical Sciences University Of Shizuoka

• Achiwa Kazuo

  School Of Pharmaceutical Sciences(laboratory Of Medicinal Chemistry)

• EBIIKE Hirosato

  School of Pharmaceutical Sciences, University of Shizuoka

• MARUYAMA Kaori

  School of Pharmaceutical Sciences, University of Shizuoka

• OZAWA Yumi

  School of Pharmaceutical Sciences, University of Shizuoka

• YAMAZAKI Yukiyoshi

  School of Pharmaceutical Sciences, University of Shizuoka

• Ebiike H

  School Of Pharmaceutical Sciences University Of Shizuoka

• Ebiike Hirosato

  School Of Pharmaceutical Sciences University Of Shizuoka

• Ozawa Y

  School Of Pharmaceutical Sciences University Of Shizuoka

• 桐山 美由紀

  Meiji Pharmaceutical Univ. Tokyo Jpn

• Maruyama K

  Kyoto Pharmaceutical University

• 山嵜 行由

  School Of Pharmaceutical Sciences University Of Shizuoka

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