Specific Inhibition of Hypoxia-inducible Factor (HIF)-1α Activation and of Vascular Endothelial Growth Factor (VEGF) Production by Flavonoids(Biochemistry/Molecular Biology)

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概要

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• Screening using a reporter under the control of the hypoxia-response element (HRE) identified several flavonoids and homoisoflavonoids that inhibit the activation of HRE under hypoxic conditions. Among various compounds, isorhamnetin, luteolin, quercetin, and methyl ophiopogonanone B (MOB) were effective at 3 to 9μg/ml in inhibiting the reporter activity. The expression of vascular endothelial growth factor (VEGF) mRNA during hypoxia was also inhibited by MOB in HepG2 cells, but the effective doses were 10 to 20μg/ml. MOB caused destabilization of hypoxia-inducible factor (HIF)-1α, as revealed by Western blotting, that was dependent on proteasome activity and the tumor suppressor, p53. The tubular formation and migration of human umbilical vein endothelial cells was also inhibited by MOB. MOB is expected to act as an inhibitor of angiogenesis.

• 公益社団法人日本薬学会の論文
• 2003-10-01

著者

• Kondo S

  Institute Of Microbial Chemistry

• Hirai Yasuaki

  昭和大学 薬学部

• Hirai Yasuaki

  Showa Univ. Tokyo Jpn

• Ida Yoshiteru

  Departments Of Clinical Pharmacy And Phytochemistry School Of Pharmaceutical Sciences Showa Universi

• Ida Yoshiteru

  Department Of Pharmacognosy And Phytochemistry Showa University Of Pharmaceutical Sciences

• KUNIMOTO Setsuko

  Institute of Microbial Chemistry

• NOSE Kiyoshi

  Department of Microbiology, Showa University School of Pharmacy

• Hirai Yasuaki

  Department Of Pharmacognosy And Phytochemistry Showa University Of Pharmaceutical Sciences

• HASEBE Yuki

  Department of Microbiology, Showa University of Pharmaceutical Sciences

• EGAWA Kiyoshi

  Department of Microbiology, Showa University of Pharmaceutical Sciences

• YAMAZAKI Yoko

  Institute ofMicrobial Chemistry

• Yamazaki Yohko

  微生物化学研究会微生物化学研究センター沼津創薬医科学研究所

• Hasebe Yuki

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Nose K

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Nose K

  Showa Univ. Pharmaceutical Sci. Tokyo Jpn

• Nose Kiyoshi

  Department Of Microbioilogy Showa University School Of Pharmaceutical Sciences

• KUNIMOTO Setsuko

  Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center

• Nose Kiyoshi

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Yamazaki Yoko

  Numazu Bio-medical Research Institute Microbial Chemistry Research Center

• Hori Yumiko

  School Of Pharmaceutical Sciences Showa University

• Egawa K

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Egawa Kiyoshi

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Kunimoto S

  Numazu Bio-medical Research Institute Microbial Chemistry Research Center

• Hori Yumiko

  School Of Pharmacy Showa University

• 山嵜 行由

  School Of Pharmaceutical Sciences University Of Shizuoka

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