Deoxynybomycin Is a Selective Anti-Tumor Agent Inducing Apoptosis and Inhibiting Topoisomerase I

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概要

• 論文の詳細を見る

• Deoxynybomycin was identified as an inducer of p21 the/WAF1 gene following screening using a reporter, p21/luciferase. The present study examined its anti-proliferative effect on human tumor cell lines. Deoxynybomycin selectively inhibited growth of human osteoblastic sarcoma Saos-2,gastric cancer TMK-1,and monocytic leukemia THP-1 cells, but did not affect survival of normal human fibroblasts at doses up to 5 μg/ml. Results from an assay system using a panel of 39 human cancer cell lines indicated that deoxynybomycin has selective cytotoxic activity against lung carcinoma cell lines. Deoxynybomycin induced apoptosis in Saos-2,TMK-1,and THP-1 cells as revealed by DNA fragmentation and TUNEL assays. It inhibited topoisomerase I but not topoisomerase II. These results suggest that deoxynybomycin may be useful in cancer chemothrerapy.

• 公益社団法人日本薬学会の論文
• 2000-09-01

著者

• TAKEUCHI Tomio

  Institute of Microbial Chemistry

• Kondo S

  Institute Of Microbial Chemistry

• Takeuchi T

  Bioresource Laboratories Mercian Corp.

• Takeuchi T

  Institute Of Microbial Chemistry

• Yamori Takao

  Cancer Chemotherapy Center Japanese Foundation For Cancer Research

• Yamori Takao

  Cancer Chemotherapy Center Cancer Center

• KUNIMOTO Setsuko

  Institute of Microbial Chemistry

• EGAWA Kiyoshi

  Department of Microbiology, Showa University of Pharmaceutical Sciences

• Nose K

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Nose K

  Showa Univ. Pharmaceutical Sci. Tokyo Jpn

• KUNIMOTO Setsuko

  Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center

• NOSAKA Chisato

  Institute of Microbial Chemistry

• NOSE Kiyoshi

  Institute of Microbial Chemistry

• TAKIZAWA Toshio

  Teikyo University Institute of Medical Mycology

• Takeuchi Toshio

  Research And Development Department Kibun Food Chemifa Co. Ltd.

• Nose Kiyoshi

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Egawa K

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Egawa Kiyoshi

  Department Of Microbiology Showa University Of Pharmaceutical Sciences

• Kunimoto S

  Numazu Bio-medical Research Institute Microbial Chemistry Research Center

• Takeuchi Tomio

  Institute For Chemotherapy M.c.r.f.

• Yamori Takao

  Cancer Chemotherapy Center

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