Synthesis and Cytoprotective Antiulcer Activity of 2- or 4-(1H-Pyrazol-1-yl)pyrimidine Derivatives Related to Mepirizole and Dulcerozine
スポンサーリンク
概要
- 論文の詳細を見る
(1H-Pyrazol-1-yl)-, (1H-imidazol-1-yl)-, and (1H-1,2,4-triazol-1-yl)phrimidines were prepared and evaluated for cytoprotective antiulcer activity. Among them, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)pyrimidine (18) showed potent inhibition of the HCl-ethanol-induced and water-immersion stress-induced ulcers in rats, as well as low acute toxicity.
- 公益社団法人日本薬学会の論文
- 1996-09-15
著者
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Maruyama K
帝京大学 薬 薬剤
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YAMADA Tatsuhiko
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
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IKEDA Masazumi
Kyoto Pharmaceutical University
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Yamada T
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Okabe S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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MARUYAMA Kazumi
Kyoto Pharmaceutical University
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NOBUHARA Youichi
Nissin Food Products Co., Ltd.,
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YAMADA Toshihiro
Nissin Food Products Co., Ltd.,
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OKABE Susumu
Kyoto Pharmaceutical University
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Nobuhara Yoichi
Central Research Institute Nissin Food Products Co. Ltd.
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Yamada Takehisa
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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桐山 美由紀
Meiji Pharmaceutical Univ. Tokyo Jpn
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Nobuhara Youichi
Central Research Institute Nissin Food Products Co. Ltd.
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Maruyama K
Kyoto Pharmaceutical University
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