Preventive Effect of Coriandrum sativum (Chinese Parsley) on Aluminum Deposition in ICR Mice
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概要
- 論文の詳細を見る
The preventive effect of Coriandrum sativum, Fam. UMBELLIFERAE (Chinese parsley) on aluminum (Al) deposition was investigated in male ICR mice given Al (1000 ppm) as Al chloride in drinking water for 39 days. Administration of Chinese parsley to mice by gastric intubation was performed for 25 days from day 14 after the start of Al exposure, up to the end of the experiment. Concentrations of Al in the tissues were analyzed by kinetic-differentiation mode HPLC with fluorescence detection. After Al exposure, Al was found to accumulate in the brain, kidney, and femur. Al accumulation in the liver remained unchanged despite Al exposure. The localized Al depositions in the tissues were decreased by 1,2-dimethyl-3-hydroxypyrid-4-one (L1, deferiprone), a control chelating agent used to validate this experimental model. Administration of Chinese parsley also decreased Al deposition in the tissues. These results suggest that Chinese parsley has suppressive activity on Al deposition.
- 日本生薬学会の論文
- 2002-10-20
著者
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IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Ikeda M
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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IWAKI Kanso
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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FUKUDA Shigeharu
Amase Institute, Hayashibara Biochemical Laboratories, Inc.
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Fukuda S
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Iwaki Kanso
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kurimoto Masashi
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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USHIO Shimpei
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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AGA Miho
From the Fujisaki Institute, Hayashihara Biochemical Laboratories
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AGA Miho
Fujisaki Institute, Hayashibara Biochemical Laboratories. Inc.
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MASAKI Naoya
Amase Institute, Hayashibara Biochemical Laboratories, Inc.
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Masaki Naoya
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Aga M
From The Fujisaki Institute Hayashihara Biochemical Laboratories
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Maruta K
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Masaki Naoya
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Ikeda Masao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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