Distribution of a Novel Protein AgK114 Expression in the Normal Tissues of Adult Mice : Dual Expression of AgK114 and Growth Hormone in Anterior Pituitary Cells(Endocrinology)

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概要

• 論文の詳細を見る

• The novel antigen K114 (AgK114) has been previously identified in normal hamster skin, and its expression has been up-regulated accompanying tissue damages of the skin, although there is no information on its biological functions. To determine the physiological role of AgK114, we prepared anti- mouse AgK114 monoclonal antibody and studied its tissue distribution in healthy adult mice by immunocytochemistry. A widespread and unique expression of AgK114 peptide was found in the selected organs of various systems (hair follicle cells and sebaceous gland of skin, ciliated epithelial cells of trachea and bronchial tube, striated portion of submandibular gland, distal convoluted tubule cells of kidney, ciliated epithelial cells of oviduct, medulla of adrenal gland and anterior lobe of pituitary gland). Interestingly, dual expression of AgK1 14 peptide and growth hormone in somatotrophs was found in anterior lobe of pituitary gland by double immunocytochemistry. AgK114 peptide was expressed widely in many regionally well- defined cellular systems in various peripheral tissues, suggesting that AgK114 peptide may have some roles of physiological functions in these organs. The data from our current study have provided a rationale for further studies of functional roles of AgK1 14 peptide in a variety of organs or tissues under physiological conditions.

• 社団法人日本動物学会の論文
• 2005-09-25

著者

• KURIMOTO Masashi

  Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.

• Kohguchi Michihiro

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Kibata Masayoshi

  Hayashibara Biochemical Laboratories Inc.

• Kurimoto Masashi

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Mori Tetsuya

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Ohta Tsunetaka

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Takeuchi M

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Takeuchi Makoto

  Chemistry Research Laboratories Astellas Pharmaceutical Inc.

• Takeuchi M

  Chemistry Research Laboratories Astellas Pharmaceutical Inc.

• Takeuchi Makoto

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Kubota Michio

  Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.

• Kurose Mayumi

  Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.

• Mukai Kazuhisa

  Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.

• Okura Takanori

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• TATEFUJI Tomoki

  Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.

• KAYANO Tohru

  Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.

• Takeuchil Makoto

  Drugs, Cosmetics & Chemicals Development Center, Hayashibara Biochemical Laboratories Inc.

• Kayano Tohru

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Kubota M

  Hayashibara Biochemical Laboratories Inc.

• Tatefuji Tomoki

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Kurimoto M

  Fujisaki Institute Hayashibam Biochemical Laboratories Inc.

• Maruta K

  Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.

• Tatefuji T

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Takeuchi Makoto

  Drugs, Cosmetics & Chemicals Development Center, Hayashibara Biochemical Laboratories Inc.

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