The Effect of AgK114 on Wound Healing(Highlighted paper selected by Editor-in-chief,Molecular and Cell Biology)

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概要

• 論文の詳細を見る

• AgK114 is a newly isolated membrane-associated protein which is expressed on keratinocytes. Its expression is restricted to dermal sheath cells near sebaceous glands in normal skin. However, it is transiently induced by UV exposure or injury stimulation (Tatefuji T. et al., Biol. Pharm. Bull., 27, 1742-1749, 2004). Thus, the expression pattern of AgK114 suggested its potential role in wound healing response. We report here that expression of AgK114 is induced in the initial 24 h at the edge keratinocytes during keratinocyte migration, followed by disappearance once epithelialization is completed in the murine excisional wound model. We also demonstrate that exogenous recombinant mouse AgK114FL promoted wound healing process. Mouse AgK114FL up-regulated pro-matrix-metalloproteinase-9, vascular endotherial growth factor, transforming growth factor-β, IL-6, and IL-1β production in the early stage of wound tissue. Moreover, mouse AgK114FL induced the matrix-metalloproteinase-9 activity of wound fibroblasts prepared from impaired skin in the presence of proinflammatory cytokines. These results suggest that the AgK114 participates in the wound response during the healing process, and promotes wound repair.

• 公益社団法人日本薬学会の論文
• 2006-05-01

著者

• KURIMOTO Masashi

  Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.

• Kohguchi Michihiro

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Kibata Masayoshi

  Hayashibara Biochemical Laboratories Inc.

• Kurimoto Masashi

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Mori Tetsuya

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Arai Chikako

  Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.

• Ohta Tsunetaka

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Takeuchi M

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Takeuchi Makoto

  Chemistry Research Laboratories Astellas Pharmaceutical Inc.

• Takeuchi M

  Chemistry Research Laboratories Astellas Pharmaceutical Inc.

• Takeuchi Makoto

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Mizote Akiko

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Arai C

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Arai Chikako

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Kubota Michio

  Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.

• Kurose Mayumi

  Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.

• Mukai Kazuhisa

  Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.

• Okura Takanori

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• TATEFUJI Tomoki

  Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.

• OKUDA Yasunori

  Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.

• KAYANO Tohru

  Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.

• Kayano Tohru

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Okuda Yasunori

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Kubota M

  Hayashibara Biochemical Laboratories Inc.

• Tatefuji Tomoki

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Kurimoto M

  Fujisaki Institute Hayashibam Biochemical Laboratories Inc.

• Maruta K

  Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.

• Tatefuji T

  Fujisaki Institute Hayashibara Biochemical Laboratories Inc.

• Takeuchi Makoto

  Fujisaki Insitute Hayashibara Biochemical Laboratories Inc.

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