Lumin, a Cyanine Dye, Enhances Interleukin 12-Dependent Interferon Gamma Production by Lipopolysaccharide-Stimulated Mouse Splenocytes
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概要
- 論文の詳細を見る
Lumin was orally administered to mice daily for 3 d, and on the day following the final administration, mice were sacrificed and splenocytes were stimulated with lipopolysaccharide (LPS). Splenocytes obtained from lumin-treated mice showed enhanced production of interferon r (IFN-γ) and increased percentages of CD3^+ cells. Although T cells are considered to be the source of IFN-γ, it is unlikely that LPS directly stimulates T cells. Next we performed neutralization experiments using a monoclonal antibody (mAb) against interleukin (IL-)12 because this cytokine, which is produced by macrophages, has the direct ability to induce IFN-γ production and the proliferation of activated T cells. This antibody inhibited IFN-γ production by splenocytes. We thus show that orally administered lumin enhances IFN-γ production by splenocytes when the latter are stimulated with LPS, a phenomenon that was observed in correlation with activation of T cells by IL-12, that is produced by macrophages.
- 社団法人日本薬学会の論文
- 2002-08-01
著者
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IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Ishihara Tatsuya
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Ikeda M
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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KUNIKATA Toshio
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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ISHIHARA Tatsuya
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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USHIO Shimpei
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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IWAKI Kanso
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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IKEDA Masao
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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KURIMOTO Masashi
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Ushio Shimpei
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Iwaki Kanso
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Kunikata T
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Kimoto Tetsuo
Hayashibara Biochemical Laboratories Inc. Fujisaki Institute
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Maruta K
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda Masao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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