Control of Chemoselectivity in Dirhodium(II)-Catalyzed Reaction of 5,6-Dioxygenated 2-Diazo-3-oxohexanoates : C-H Insertion Reaction versus Oxonium Ylide Formation
スポンサーリンク
概要
- 論文の詳細を見る
Methyl (S)-2-diazo-4-(3,3-dimethyl-2,4-dioxolan-1-yl)-3-oxobutanoate (1), upon treatment with Rh_2(OAc)_4 in boiling dichloromethane, gave methyl (1S, 5S)-2,2-dimethyl-7-oxo-3,8-dioxabicyclo[3.2.1]octane-1-carboxylate (2) via oxonium ylide formation/1,2-shift. On the other hand, similar treatment of methyl (S)-5,6-bis(tert-butyldimethylsilyloxy)-2-diazo-3-oxohexanoate (3a) gave methyl 3-(tert-butyldimethylsilyloxy)-5-oxo-1-cyclopentene-1-carboxylate (4a) via the C-H insertion reaction.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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YAKURA Takayuki
Kyoto Pharmaceutical University
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IKEDA Masazumi
Kyoto Pharmaceutical University
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UEKI Akiharu
Kyoto Pharmaceutical University
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Tamura Y
Kyoto Pharmaceutical University
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MORIOKA Yukiko
Kyoto Pharmaceutical University
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KURATA Toyoshige
Kyoto Pharmaceutical University
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TANAKA Kenji
Kyoto Pharmaceutical University
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Morioka Y
Kyoto Pharmaceutical University
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