Approaches to the Cephalotaxine Skeleton Using an Intramolecular Heck Reaction
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概要
- 論文の詳細を見る
1-[2-(o-Iodophenyl)acetyl]-2-(prop-2-enyl)-2-vinylpyrrolidine (17), upon treatment with palladium(II) acetate [Pd(OAc)_2] in the presence of triphenylphosphine and triethylamine in refluxing acetonitrile, gave the monocyclization product 20 as the major product along with a small amount of the tandem cyclization product 21. On the other hand, treatment of the 1-[2-(o-iodophenyl)acetyl]-1-azaspiro[4.4]non-8-en-7-one (25) with Pd(OAc)_2,1,3-bis-(diphenylphosphino)propane, tributylphosphine, and silver carbonate in boiling N, N-dimethylformamide afforded the cyclized product 27 in 51% yield.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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Bayomi S
Univ. Mansoura Mansoura Egy
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EL BIALY
Kyoto Pharmaceutical University
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HIROSE Ken-ichi
Kyoto Pharmaceutical University
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SATO Tatsunori
Kyoto Pharmaceutical University
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BAYOMI Said
Faculty of Pharmacy, University of Mansoura
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YAKURA Takayuki
Kyoto Pharmaceutical University
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IKEDA Masazumi
Kyoto Pharmaceutical University
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Sato T
Tanabe Seiyaku Co. Ltd. Osaka Jpn
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Hirose K
Molecular Cell Biology Team Biomedical Research Laboratories Kureha Chemical Ind. Co. Ltd.
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Bayomi Said
Faculty Of Pharmaceutical Sciences Osaka University
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Tamura Y
Kyoto Pharmaceutical University
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