Antiviral Effect of Polygonum tinctorium Lour. Extracts on Virus-Infected Cells
スポンサーリンク
概要
- 論文の詳細を見る
A crude extract of Polygonum tinctorium Lour. (P. tinctorium) has been demonstrated to have a variety of biological activities including anti-inflammatory effects. In this paper, we found that both methanol and ethyl acetate extracts of P. tinctorium inhibited the replication of viruses including vesicular stomatitis virus (VSV), influenza virus A/PR/8/34, vaccinia virus (VV), human herpes simplex virus type-1 (HSV-1) and mouse cytomegalo virus (MCMV). The methanol extract had the 50% inhibitory concentration of 6.25 μg/ml on VSV and the ethyl acetate had that of 25 μg/ml without any toxicity on the target cells. The water extract did not show any antiviral effects on these viruses. Addition of P. tinctorium extracts during the viral infection period apparently augmented the cell viabilty. These results suggest that P. tinctorium contains some antiviral substances inhibiting both the viral replication in infected cells and the viral infection of the target cells.
- 日本生薬学会の論文
- 1999-12-20
著者
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Ikeda M
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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KUNIKATA Toshio
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Kurimoto Masashi
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Kunikata T
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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AGA Miho
From the Fujisaki Institute, Hayashihara Biochemical Laboratories
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AGA Miho
Fujisaki Institute, Hayashibara Biochemical Laboratories. Inc.
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Aga M
From The Fujisaki Institute Hayashihara Biochemical Laboratories
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Kimoto Tetsuo
Hayashibara Biochemical Laboratories Inc. Fujisaki Institute
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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TATEFUJI Tomoki
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Tatefuji Tomoki
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Iked Masao
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Ikeda Masao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Kunikata Toshio
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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