Bioavailability of Glucosyl Hesperidin in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Glucosyl hesperidin (G-hesperidin) is a water-soluble derivative of hesperidin. We compared the absorption and metabolism of G-hesperidin with those of hesperidin in rats. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with β-glucuronidase, but it was not detectable in unhydrolyzed sera. Serum hesperetin was found more rapidly in rats administered G-hesperidin than in those administered hesperidin. The area under the concentration-time curve for hesperetin in the sera of rats administered G-hesperidin was approximately 3.7-fold greater than that of rats administered hesperidin. In the urine of both administration groups, hesperetin and its glucuronide were found. Urinary excretion of metabolites was higher in rats administered G-hesperidin than in those administered hesperidin. These results indicate that G-hesperidin presents the same metabolic profile as hesperidin. Moreover, it was concluded that G-hesperidin is absorbed more rapidly and efficiently than hesperidin, because of its high water solubility.
- 社団法人 日本農芸化学会の論文
- 2006-06-23
著者
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Chaen Hiroto
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Institute Hayashibara Biochemical Laboratories Inc.
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Chaen H
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Hayashibara Biochemical Laboratories Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Kibata Masayoshi
Hayashibara Biochemical Laboratories Inc.
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Miwa Yoshikatsu
Hayashibara Biochemical Laboratories, Inc.
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YAMADA Mika
Hayashibara Biochemical Laboratories, Inc.
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TANABE Fujimi
Hayashibara Biochemical Laboratories, Inc.
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ARAI Norie
Hayashibara Biochemical Laboratories, Inc.
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MITSUZUMI Hitoshi
Hayashibara Biochemical Laboratories, Inc.
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KUBOTA Michio
Hayashibara Biochemical Laboratories, Inc.
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Mitsuzumi Hitoshi
Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Arai Norie
Hayashibara Biochemical Laboratories Inc.
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Yamada Mika
Hayashibara Biochemical Laboratories Inc.
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Kubota Michio
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Kubota Michio
Hayashibara Biochemical Laboratories Inc.
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Mishima Yasuo
Division Of Internal Medicine National Minami Okayama Hospital
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Miwa Yoshikatsu
Hayashibara Biochemical Laboratories Inc.
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Kubota M
Hayashibara Biochemical Laboratories Inc.
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Kubota M
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Tanabe Fujimi
Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Fujisaki Institute Hayashibam Biochemical Laboratories Inc.
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Maruta K
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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