Suppression of Apolipoprotein B Secretion from HepG2 Cells by Glucosyl Hesperidin
スポンサーリンク
概要
- 論文の詳細を見る
Our previous study has shown that a soluble hesperidin derivative, glucosyl hesperidin (G-hesperidin), preferentially lowers serum triglyceride (TG) level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein (VLDL) metabolic abnormality. G-Hesperidin has also been found to decrease an elevated serum apolipoprotein B (apo B) level in the hypertriglyceridemic subjects, suggesting a possibility that this compound suppresses excess VLDL secretion in the liver. In the present study, to gain a better understanding of possible mechanisms by which G-hesperidin lowers serum TG, we examined whether this derivative affects apo B secretion from HepG2 human hepatoma cells, a model of hepatic VLDL secretion. As a result, G-hesperidin significantly reduced apo B secretion from the oleate-stimulated HepG2 cells. Furthermore, G-hesperidin significantly suppressed apo B secretion only in the oleate-stimulated cells and failed to act on the cells incubated without oleate. In the oleate-stimulated cells, G-hesperidin significantly decreased cellular cholesteryl ester (CE), although it had no effect on cellular TG or free cholesterol amounts. Moreover, the oleate-stimulated cells had a decrease in cellular apo B amounts by G-hesperidin exposure. These findings indicate that G-hesperidin down-regulates the assembly of apo B-containing lipoproteins via the reduction of CE synthesis augmented with oleate and results in suppressing excess apo B secretion from the cells. This effect is speculated to be associated with the improvement of VLDL metabolic abnormality in hypertriglyceridemic subjects and considered as a mechanism of lowering serum TG.
- 日本ビタミン学会の論文
著者
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Chaen Hiroto
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Institute Hayashibara Biochemical Laboratories Inc.
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Chaen H
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Hayashibara Biochemical Laboratories Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Kibata Masayoshi
Hayashibara Biochemical Laboratories Inc.
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Miwa Yoshikatsu
Hayashibara Biochemical Laboratories, Inc.
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Okada Katsuhide
Hayashibara Co. Ltd.
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YAMADA Mika
Hayashibara Biochemical Laboratories, Inc.
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TANABE Fujimi
Hayashibara Biochemical Laboratories, Inc.
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ARAI Norie
Hayashibara Biochemical Laboratories, Inc.
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MITSUZUMI Hitoshi
Hayashibara Biochemical Laboratories, Inc.
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KUBOTA Michio
Hayashibara Biochemical Laboratories, Inc.
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SUNAYAMA Takahiro
Dai-ichi Central Bldg.
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Mitsuzumi Hitoshi
Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Arai Norie
Hayashibara Biochemical Laboratories Inc.
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Yamada Mika
Hayashibara Biochemical Laboratories Inc.
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Kubota Michio
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Kubota Michio
Hayashibara Biochemical Laboratories Inc.
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Mishima Yasuo
Division Of Internal Medicine National Minami Okayama Hospital
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Miwa Yoshikatsu
Hayashibara Biochemical Laboratories Inc.
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Kubota M
Hayashibara Biochemical Laboratories Inc.
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Kubota M
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Tanabe Fujimi
Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Fujisaki Institute Hayashibam Biochemical Laboratories Inc.
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Maruta K
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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