Promoting Effect of Kaempferol on the Differentiation and Mineralization of Murine Pre-osteoblastic Cell Line MC3T3-E1(Food & Nutrition Science)
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概要
- 論文の詳細を見る
A number of agents have been reported to influence osteoblastic differentiation and to prevent and treat bone loss. We found that kaempferol, a flavonoid identified in extracts of the medicinal plant, Polygonum tinctorium. Lour, had stimulatory effects on the differentiation and mineralization of the murine preosteoblastic cell line, MC3T3-E1. After enhancing the alkaline phosphatase activity, significant augmentation of calcification by kaempferol was observed between concentrations of 10 and 20 μM, without any marked effect on cell proliferation. When kaempferol was combined with ipriflavone, which is clinically applied to treat bone loss, calcification was synergistically augmented, suggesting that these two flavonoids may have different mechanisms of action. These results suggest that kaempferol may be a promising agent for the prevention or treatment of bone loss, especially when combined with ipriflavone.
- 社団法人日本農芸化学会の論文
- 2003-06-23
著者
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Miyake Masaki
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Ikeda M
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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IWAKI Kanso
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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IKEDA Masao
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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KURIMOTO Masashi
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Ushio Shimpei
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Iwaki Kanso
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Kurimoto Masashi
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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USHIO Shimpei
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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ARAI Norie
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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MIYAKE Masaki
Fujisaki Institute, Hayashibara Biochemical Laboratories Inc.
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ARAI Norie
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Micallef Mark
Hayashibara Biochemical Laboratories Inc. Fujisaki Institute
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Miyake M
Biomedical Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Maruta K
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda Masao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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