Inhibitory Effects of 2-Amino-3H-phenoxazin-3-one on the Melanogenesis of Murine B16 Melanoma Cell Line
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概要
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Hyperpigmentations are a serious concern addressed by both the medical community and the cosmetic industry through the development of agents that block melanin biosynthesis. In this study, we found that 2-amino-3H-phenoxazin-3-one (APO), isolated from extracts of the edible mushroom Agaricus bisporus Imbach, exhibited potent inhibitory effects on melanogenesis in B16 cells, a murine melanoma cell line. APO inhibited melanin biosynthesis at 1,000 times lower concentrations (IC50=1.31±0.08 μM) than kojic acid (IC50=1.31±0.13 mM), without causing cellular toxicity. APO did not directly inhibit the enzyme activity of tyrosinase, the rate-limiting melanogenic enzyme. Further study showed that APO inhibited the protein expression of tyrosinase and microphthalmia-associated transcription factor (MITF), a melanogenic transcription factor that regulates the expression of tyrosinase. These results suggest that APO is a promising depigmenting agent with both therapeutic and cosmetic value in preventing melanogenesis.
著者
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Miyake Masaki
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Yamamoto Shigeto
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Sano Osamu
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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FUJII Mitsukiyo
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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KOHNO Keizo
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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USHIO Shimpei
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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FUKUDA Shigeharu
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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