Propolis Prevents Diet-Induced Hyperlipidemia and Mitigates Weight Gain in Diet-Induced Obesity in Mice
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概要
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We examined the hypolipidemic effect of propolis in a mouse obesity model induced by a high fat-diet. C57BL/6N mice were fed a high-fat diet ad libitum and given propolis extract intragastrically at 0 mg/kg (control), 5 mg/kg or 50 mg/kg twice daily for 10 d. Compared with mice in the control group, mice in the propolis extract-administrated groups displayed a reduction in all of the following parameters: body weight gain, weight of visceral adipose tissue, liver and serum triglycerides, cholesterol, and non-esterified fatty acids. Real-time polymerase chain reaction analysis of the liver showed down-regulation of mRNA expression associated with fatty acid biosynthesis, including fatty acid synthase, acetyl-CoA carboxylase α, and sterol regulatory element binding protein in the propolis-administrated mice. Subsequently, obese C57BL/6N mice that had been administered a high-fat diet were given propolis extract at 0 mg/kg (control), 2.5 mg/kg or 25 mg/kg for 4 weeks. The propolis extract treated mice showed a decrease in weight gain, a reduction of serum non-esterified fatty acids, and lipid accumulation in the liver. These results suggest that propolis extract prevented and mitigated high-fat diet-induced hyperlipidemia by down-regulating the expression of genes associated with lipid metabolism.
- 公益社団法人 日本薬学会の論文
著者
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USHIO Shimpei
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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FUKUDA Shigeharu
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Ushio Shimpei
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Iwaki Kanso
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Koya Satomi
Hayashibara Biochemical Laboratories Inc. Fujisaki Institute
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ARAI Norie
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Koya-Miyata Satomi
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Fukuda Shigeharu
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Mizote Akiko
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Taniguchi Yoshifumi
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Koya-miyata Satomi
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Mizote Akiko
Biomedical Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Taniguchi Yoshifumi
Biomedical Institute Research Center Hayashibara Biochemical Laboratories Inc.
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