Tryptanthrin Inhibits Interferon-γ Production by Peyer's Patch Lymphocytes Derived from Mice That Had Been Orally Administered Staphylococcal Enterotoxin
スポンサーリンク
概要
- 論文の詳細を見る
Tryptanthrin, a biologically active compound found in the medicinal plant Polygonum tinctorium, reportedly has several biological activities. We investigated the effects of tryptanthrin on cytokine production by lymphocytes in response to Staphylococcal enterotoxin B (SEB), which causes a variety of disorders in humans based on its induction of large amounts of immunostimulatory cytokines. Tryptanthrin dose-dependently inhibited interferon-γ (IFN-γ) and interleukin-2 production by mouse spleen cells and Peyer's patch (PP) lymphocytes in vitro. The efficacy of tryptanthrin was further studied in a mouse model in vivo. Tryptanthrin was administered orally 2 h after an oral challenge with SEB. Nineteen hours after SEB administration, PP lymphocytes were prepared, and IFN-γ production by PP lymphocytes was examined. The production of IFN-γ increased after SEB administration, and the elevated IFN-γ production was significantly inhibited by tryptanthrin treatment. These results suggest that tryptanthrin may be effective in the treatment of disorders of the intestines, such as food poisoning, that are associated with activated lymphocytes.
- 社団法人日本薬学会の論文
- 2003-03-01
著者
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IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Ikeda M
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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KUNIKATA Toshio
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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IWAKI Kanso
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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IKEDA Masao
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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KURIMOTO Masashi
From the Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Ushio Shimpei
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Iwaki Kanso
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Kunikata T
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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TAKEI Yasuhiko
From the Fujisaki Institute, Hayashihara Biochemical Laboratories
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AGA Miho
From the Fujisaki Institute, Hayashihara Biochemical Laboratories
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INOUE Shin-ichiro
From the Fujisaki Institute, Hayashihara Biochemical Laboratories
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USIO Shimpei
From the Fujisaki Institute, Hayashihara Biochemical Laboratories
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Takei Yasuhiko
From The Fujisaki Institute Hayashihara Biochemical Laboratories
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Inoue Shin-ichiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Aga M
From The Fujisaki Institute Hayashihara Biochemical Laboratories
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Kimoto Tetsuo
Hayashibara Biochemical Laboratories Inc. Fujisaki Institute
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Maruta K
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Aga Miho
From The Fujisaki Institute Hayashihara Biochemical Laboratories
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Ikeda Masao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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