Effects of Dietary Lactosucrose (4G-β-D-galactosylsucrose) on the IgE Response in Mice
スポンサーリンク
概要
- 論文の詳細を見る
In this study, we examined the effects of dietary lactosucrose (LS, a non-digestible oligosaccharide) on the IgE response in mice immunized with ovalbumin (OVA)/alum. In addition to IgG1 and IgG2a responses, the anti-OVA IgE response in mice fed LS diets was dose-dependently suppressed, as compared with the control mice, while the serum total IgG levels were comparable. Moreover, dietary LS feeding inhibited antigen-specific IgE and IgG1 productions even after a second immunization. Regarding with cytokine production, when stimulated in vitro with OVA, splenocytes obtained from LS-fed mice produced a similar level of IFN-γ, and lower levels of IL-4 and IL-5, as compared with the control mice. But IL-10 production by OVA-stimulated splenocytes was augmented in LS-fed mice, suggesting that IL-10 producing cells are responsible for the immunoregulatory effect of LS. Our findings indicate the further possibility that dietary LS supplementation can be used to prevent IgE-mediated allergic diseases.
著者
-
Chaen Hiroto
Glycoscience Institute, Hayashibara Biochemical Laboratories, Inc.
-
KOHNO Keizo
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
FUKUDA Shigeharu
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
Oku Kazuyuki
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
-
Mizote Akiko
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
Taniguchi Yoshifumi
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
Kohno Keizo
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
関連論文
- Improved yields of cyclic nigerosylnigerose from starch by pretreatment with a thermostable branching enzyme(BIOCHEMICAL ENGINEERING)
- Inhibitory Effects of 2-Amino-3H-phenoxazin-3-one on the Melanogenesis of Murine B16 Melanoma Cell Line
- Immuno-potentiating Effects of the Antler-shaped Fruiting Body of Ganoderma lucidum (Rokkaku-Reishi)
- Lumin, a Cyanine Dye, Enhances Interleukin 12-Dependent Interferon Gamma Production by Lipopolysaccharide-Stimulated Mouse Splenocytes
- Effect of Royal Jelly Diet on the Testicular Function of Hamsters
- Effects of Dietary Lactosucrose (4G-β-D-galactosylsucrose) on the IgE Response in Mice
- Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism
- Royal Jelly Inhibits the Production of Proinflammatory Cytokines by Activated Macrophages
- Promoting Effect of Kaempferol on the Differentiation and Mineralization of Murine Pre-osteoblastic Cell Line MC3T3-E1(Food & Nutrition Science)
- Tryptanthrin Inhibits Interferon-γ Production by Peyer's Patch Lymphocytes Derived from Mice That Had Been Orally Administered Staphylococcal Enterotoxin
- Preventive Effect of Coriandrum sativum (Chinese Parsley) on Aluminum Deposition in ICR Mice
- Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin, an active ingredient of Polygonum tinctorium Lour
- Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils
- Saccharomyces cerevisiae Rot1p Is an ER-Localized Membrane Protein That May Function with BiP/Kar2p in Protein Folding
- Metastasis-Promoting Activity of a Novel Molecule, Ag 243-5, Derived from Mycoplasma, and the Complete Nucleotide Sequence
- Anti-inflammatory and Immunomodulatory Properties of 2-Amino-3H-phenoxazin-3-one(Pharmacognosy)
- Synthesis of Glycosyl-trehaloses by Cyclomaltodextrin Glucanotransferase through the Transglycosylation Reaction
- Effect of Dietary Cyclic Nigerosylnigerose on Intestinal Immune Functions in Mice
- Production of Isocyclomaltopentaose from Starch Using Isocyclomaltooligosaccharide Glucanotransferase
- Cloning, Sequencing, and Expression of the Genes Encoding an Isocyclomaltooligosaccharide Glucanotransferase and an α-Amylase from a Bacillus circulans Strain
- A Novel Glucanotransferase from a Bacillus circulans Strain That Produces a Cyclomaltopentaose Cyclized by an α-1,6-Linkage
- Acceptor Recognition of Kojibiose Phosphorylase from Thermoanaerobacter brockii : Syntheses of Glycosyl Glycerol and myo-Inositol(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Acceptor Specificity of Trehalose Phosphorylase from Thermoanaerobacter brockii : Production of Novel Nonreducing Trisaccharide, 6-O-α-D-Galactopyranosyl Trehalose(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Enzymatic Synthesis of Kojioligosaccharides Using Kojibiose Phosphorylase
- Enzymatic Synthesis of Novel Oligosaccharides from L-Sorbose, Maltose, and Sucrose Using Kojibiose Phosphorylase
- Action of a Thermostable Trehalose Synthase from Thermus aquaticus on Sucrose
- Synthesis by an α-Glucosidase of Glycosyl-trehaloses with an Isomaltosyl Residue
- Cyanine Dyes Attenuate Cerebral Ischemia and Reperfusion Injury in Rats
- Propolis Prevents Diet-Induced Hyperlipidemia and Mitigates Weight Gain in Diet-Induced Obesity in Mice
- Purification and Characterization of Cyclic Maltosyl-(1→6)-Maltose Hydrolase and α-Glucosidase from an Arthrobacter globiformis Strain
- Antimicrobial activity of Polygonum tinctorium Lour : extract against oral pathogenic bacteria
- 6-α-Glucosyltransferase and 3-α-Isomaltosyltransferase from Bacillus globisporus N75
- Suppressive Effect of Trehalose on Acrylamide Formation from Asparagine and Reducing Saccharides
- Enhancement of Thermostability of Kojibiose Phosphorylase from Thermoanaerobacter brockii ATCC35047 by Random Mutagenesis(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Interaction between Trehalose and Alkaline-Earth Metal Ions
- Cyclic Tetrasaccharide-Synthesizing Enzymes from Arthrobacter globiformis A19
- Enzymatic Synthesis of Glycosyl Cyclic Tetrasaccharide with 6-α-Glucosyltransferase and 3-α-Isomaltosyltransferase(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Cloning and Sequencing of Kojibiose Phosphorylase Gene from Thermoanaerobacter brockii ATCC35047(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Synthesis of 3-O-β-N-Acetylglucosaminyl Cyclic Tetrasaccharide through a Lysozyme-catalyzed Transfer Reaction(Biochemistry & Molecular Biology)
- Transglycosylation of Glycosyl Residues to Cyclic Tetrasaccharide by Bacillus stearothermophilus Cyclomaltodextrin Glucanotransferase Using Cyclomaltodextrin as the Glycosyl Donor(Biochemistry & Molecular Biology)
- Production of Cyclic Tetrasaccharide from Starch Using a Novel Enzyme System from Bacillus glob isporus C11
- Mutation of the Yeast ε-COP Gene ANU2 Causes Abnormal Nuclear Morphology and Defects in Intracellular Vesicular Transport
- Saccharomyces cerevisiae KAR2 (BiP) Gene Expression Is Induced by Loss of Cytosolic HSP70/Ssa1p through a Heat Shock Element-Mediated Pathway^1
- Thermosensitivity of Green Fluorescent Protein Fluorescence Utilized to Reveal Novel Nuclear-Like Compartments in a Mutant Nucleoporin NSP1
- Carbohydrate Structures of the Glycoprotein Allergen Cry j I from Japanese Cedar (Cryptomeria japonica) Pollen
- Enzymatic Properties of Recombinant Kojibiose Phosphorylase from Caldicellulosiruptor saccharolyticus ATCC43494
- Inhibitory Effects of 2-Amino-3H-phenoxazin-3-one on the Melanogenesis of Murine B16 Melanoma Cell Line
- Purification and Characterization of Glucosyltransferase and Glucanotransferase Involved in the Production of Cyclic Tetrasaccharide in Bacillus globisporus C11(Biochemistry & Molecular Biology)
- Cloning and Sequencing of the Genes Encoding Cyclic Tetrasaccharidesynthesizing Enzymes from Bacillus globisporus C11(Biochemistry & Molecular Biology)
- Cloning and Sequencing of the β-Fructofuranosidase gene from Bacillus sp.
- Purification and Characterization of Cyclic Maltosyl-(1→6)-Maltose Hydrolase and α-Glucosidase from an Arthrobacter globiformis Strain
- Lactosucrose Inhibits Body Fat Accumulation in Rats by Decreasing Intestinal Lipid Absorption
- Effects of Dietary Lactosucrose (4^G-β-D-galactosylsucrose) on the IgE Response in Mice
- Preventive Effect of Coriandrum sativum (Chinese Parsley) on Aluminum Deposition in ICR Mice