Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism
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概要
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We have previously shown that royal jelly (RJ) promoted collagen production by skin fibroblasts in the presence of ascorbic acid-2-O-alpha-glucoside (AA-2G). In this study, we purified the honeybee RJ-derived collagen production-promoting factor (HBRJ-CPF) from an alkali-solubilized fraction of RJ by C18 reverse-phase column chromatography. The elution profile by the C18 column chromatography and the molecular mass of the purified HBRJ-CPF material coincided with those of 10-hydroxy-2-decenoic acid (10H2DA). We then examined the collagen production-promoting activities of several commercially available fatty acids contained in RJ. We found that 10H2DA and 10-hydroxydecanoic acid increased the collagen production in a dose-dependent manner. Furthermore, 10H2DA induced the fibroblast cell line, NHDF, to produce transforming growth factor-β1 (TGF-β1) which is an important factor for collagen production. As expected, the collagen production-promoting activity of 10H2DA was neutralized by the anti-TGF-β1 antibody. These result suggest that HBRJ-CPF identified as 10H2DA promoted the collagen production of AA-2G-treated fibroblasts by inducing TGF-β1 production.
- 社団法人 日本農芸化学会の論文
- 2004-04-23
著者
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IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Ikeda M
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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IWAKI Kanso
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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IKEDA Masao
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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KURIMOTO Masashi
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Ushio Shimpei
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Iwaki Kanso
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Kurimoto Masashi
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Okamoto I
Showa Pharmaceutical University
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Okamoto Iwao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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USHIO Shimpei
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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KOYA (MIYATA)
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Koya (miyata)
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Kurimoto M
Fujisaki Institute Hayashibam Biochemical Laboratories Inc.
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Ikeda Masao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Koya-Miyata Satomi
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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