Anti-inflammatory and Immunomodulatory Properties of 2-Amino-3H-phenoxazin-3-one(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Accumulating evidence suggests that nitric oxide (NO) and prostaglandin E_2 (PGE_2) are involved in the pathogenesis of various chronic inflammatory diseases and cancer. During the course of a screening program to identify natural anti-inflammatory substances, we isolated the compound 2-amino-3H-phenoxazin-3-one (APO) from an extract of the edible brown mushroom Agaricus bisporus IMBACH. APO inhibited NO production by mouse peritoneal macrophages in response to the pro-inflammatory stimuli lipopolysaccharide (LPS) and interferon (IFN)-γ(LPS/IFN-γ) at low concentrations (IC_<50>=1.5μM) through reduced inducible NO synthase protein expression. PGE_2 production by LPS/IFN-γ-stimulated macrophages was inhibited by APO at much lower concentrations (IC_<50>=0.27μM) than those required for the inhibition of NO production. Mechanistic analysis showed that APO inhibited both cyclooxygenase (COX)-1 and COX-2 enzyme activities with almost equal selectivity. Secretion of NO and the pro-inflammatory cytokine IL-6 by IFN-r-activated RAW264.7 cells, a murine macrophage-like cell line, was also dose-dependently reduced by APO. Furthermore, APO increased the secretion of the anti-inflammatory cytokine IL-4 by antigen-stimulated T cells and promoted the polarization of CD4^+ Th cells toward the anti-inflammatory Th2 phenotype at equimolar concentrations that inhibited NO production. Our results suggested that APO induced polarization toward the Th2 subset, at least in part through the down-regulation of IL-12 production. Thus, APO appears to have potent anti-inflammatory and immunoregulatory properties that may provide a promising therapeutic strategy for the treatment of T cell-mediated inflammatory autoimmune diseases as well as for bacteria-induced chronic-inflammatory diseases.
- 社団法人日本薬学会の論文
- 2008-10-01
著者
-
Kohno K
Graduate School Of Biological Sciences Nara Institute Of Science And Technology (naist)
-
Miyake Masaki
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
Yamamoto Shigeto
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
Sano Osamu
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
FUJII Mitsukiyo
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
KOHNO Keizo
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
USHIO Shimpei
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
FUKUDA Shigeharu
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
Ushio Shimpei
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
-
Fukuda S
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
-
Fukuda Shigeharu
Glycoscience Institute Hayashibara Biochemical Laboratories Inc.
-
Iwaki Kanso
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
-
Watanabe H
林原生物化学研究所
-
Watanabe Hikaru
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
-
Koya Satomi
Hayashibara Biochemical Laboratories Inc. Fujisaki Institute
-
Tanaka(kataoka) Mari
Biomedical Institute Research Center Hayashibara Biochemical Laboratories Inc.
-
KOYA(MIYATA) Satomi
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
ARAI Norie
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
-
Fukuda Shigeharu
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
-
佐野 理
東京農工大
-
Kohno Keizo
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
-
Micallef Mark
Hayashibara Biochemical Laboratories Inc. Fujisaki Institute
-
佐野 理
東京農工大学一般教育部物理学教室
-
Fukuda Shigeharu
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
-
Fujii Mitsukiyo
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
-
Miyake M
Biomedical Institute Research Center Hayashibara Biochemical Laboratories Inc.
-
Koya-miyata Satomi
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
-
Yamamoto Shigeto
Biomedical Institute Research Center Hayashibara Biochemical Laboratories Inc.
-
Fukuda Shigeharu
Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
関連論文
- Improved yields of cyclic nigerosylnigerose from starch by pretreatment with a thermostable branching enzyme(BIOCHEMICAL ENGINEERING)
- 東京農工大学SAILプロジェクトにおける「自由課題実験」と「研究室体験配属」の実施(教育実践)
- Inhibitory Effects of 2-Amino-3H-phenoxazin-3-one on the Melanogenesis of Murine B16 Melanoma Cell Line
- 糖鎖層を持つ血管内皮細胞間隙を透過するリポソームの運動 (複雑流体の数理解析と数値解析)
- 渦輪の衝突による粒状体表面へのパターン形成 (複雑流体の数理解析と数値解析)
- 質点系力学と流体力学のはざまで(「物理学一般」の世界-今井 功先生90年の生涯に寄せて-)
- ミオシン分子の形と流体力学
- Immuno-potentiating Effects of the Antler-shaped Fruiting Body of Ganoderma lucidum (Rokkaku-Reishi)
- Lumin, a Cyanine Dye, Enhances Interleukin 12-Dependent Interferon Gamma Production by Lipopolysaccharide-Stimulated Mouse Splenocytes
- Effect of Royal Jelly Diet on the Testicular Function of Hamsters
- Effects of Dietary Lactosucrose (4G-β-D-galactosylsucrose) on the IgE Response in Mice
- Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism
- Royal Jelly Inhibits the Production of Proinflammatory Cytokines by Activated Macrophages
- Promoting Effect of Kaempferol on the Differentiation and Mineralization of Murine Pre-osteoblastic Cell Line MC3T3-E1(Food & Nutrition Science)
- Tryptanthrin Inhibits Interferon-γ Production by Peyer's Patch Lymphocytes Derived from Mice That Had Been Orally Administered Staphylococcal Enterotoxin
- Preventive Effect of Coriandrum sativum (Chinese Parsley) on Aluminum Deposition in ICR Mice
- Trehalose Ingestion Modifies Mucosal Immune Responses of the Small Intestine in Mice
- Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin, an active ingredient of Polygonum tinctorium Lour
- Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils
- Renal carcinogenesis induced by ferric nitrilotriacetate in mice, and protection from it by Brazilian propolis and Artepillin C
- Saccharomyces cerevisiae Rot1p Is an ER-Localized Membrane Protein That May Function with BiP/Kar2p in Protein Folding
- Metastasis-Promoting Activity of a Novel Molecule, Ag 243-5, Derived from Mycoplasma, and the Complete Nucleotide Sequence
- 24pQK-6 東京農工大学SAILプロジェクトにおける「自由課題実験」/「研究室体験配属」の実施(24pQK 物理教育,領域13(物理教育,物理学史,環境物理))
- 28aPS-88 渦輪の粒状体表面への衝突(領域11ポスターセッション,領域11,統計力学,物性基礎論,応用数学,力学,流体物理)
- 23aPS-82 同心二重円筒内の粘性流による砂漣の発生(23aPS 領域11ポスターセッション,領域11(統計力学,物性基礎論,応用数学,力学,流体物理))
- 鉛直に振動する粒状体薄層の座屈による撓み波と表面波 (オイラー方程式250年 : 連続体力学におけるオイラーの遺産)
- 21aRK-11 DDSのための毛細管流れの数値シミュレーションモデル(生物物理,領域12,ソフトマター物理,化学物理,生物物理)
- 24aPS-51 同心二重円筒内の粘性流による砂漣の発生とその成長(領域11ポスターセッション,領域11,統計力学,物性基礎論,応用数学,力学,流体物理)
- 24pTJ-5 鉛直に加振した粒状体薄層のパターン形成とその材質依存性(粉体・流体(交通流を含む),領域11,統計力学,物性基礎論,応用数学,力学,流体物理)
- Anti-inflammatory and Immunomodulatory Properties of 2-Amino-3H-phenoxazin-3-one(Pharmacognosy)
- Synthesis of Glycosyl-trehaloses by Cyclomaltodextrin Glucanotransferase through the Transglycosylation Reaction
- Effect of Dietary Cyclic Nigerosylnigerose on Intestinal Immune Functions in Mice
- 鉛直に加振した粒状体薄層における準結晶的パターン (複雑流体の数理II)
- 鉛直方向に振動する粒状体薄層上の粒子拡散 (複雑流体の数理)
- Production of Isocyclomaltopentaose from Starch Using Isocyclomaltooligosaccharide Glucanotransferase
- Cloning, Sequencing, and Expression of the Genes Encoding an Isocyclomaltooligosaccharide Glucanotransferase and an α-Amylase from a Bacillus circulans Strain
- A Novel Glucanotransferase from a Bacillus circulans Strain That Produces a Cyclomaltopentaose Cyclized by an α-1,6-Linkage
- Acceptor Recognition of Kojibiose Phosphorylase from Thermoanaerobacter brockii : Syntheses of Glycosyl Glycerol and myo-Inositol(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Acceptor Specificity of Trehalose Phosphorylase from Thermoanaerobacter brockii : Production of Novel Nonreducing Trisaccharide, 6-O-α-D-Galactopyranosyl Trehalose(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Hyper Expression of Kojibiose Phosphorylase Gene and Trehalose Phosphorylase Gene from Thermoanaerobacter brockii ATCC35047 in Bacillus subtilis and Selaginose Synthesis Utilizing Two Phosphorylases(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Gene Encoding a Trehalose Phosphorylase from Thermoanaerobacter brockii ATCC 35047(Biochemistry & Molecular Biology)
- Enzymatic Synthesis of Kojioligosaccharides Using Kojibiose Phosphorylase
- Enzymatic Synthesis of Novel Oligosaccharides from L-Sorbose, Maltose, and Sucrose Using Kojibiose Phosphorylase
- Action of a Thermostable Trehalose Synthase from Thermus aquaticus on Sucrose
- Synthesis by an α-Glucosidase of Glycosyl-trehaloses with an Isomaltosyl Residue
- 17pRH-1 中立浮遊する磁性流体液滴の振動磁場応答 (II)
- 28pYD-14 磁性流体の界面不安定性
- Cyanine Dyes Attenuate Cerebral Ischemia and Reperfusion Injury in Rats
- Limonoid Glucosides in Juices of Satsuma Mandarin (Citrus unshiu Marc.)
- Limonoid Glucosides in Citrus Seeds(Food & Nutrition)
- Propolis Prevents Diet-Induced Hyperlipidemia and Mitigates Weight Gain in Diet-Induced Obesity in Mice
- Antimicrobial activity of Polygonum tinctorium Lour : extract against oral pathogenic bacteria
- 6-α-Glucosyltransferase and 3-α-Isomaltosyltransferase from Bacillus globisporus N75
- 15aTC-4 Shape Segregation in Granular Materials
- Enhancement of Thermostability of Kojibiose Phosphorylase from Thermoanaerobacter brockii ATCC35047 by Random Mutagenesis(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Interaction between Trehalose and Alkaline-Earth Metal Ions
- Cyclic Tetrasaccharide-Synthesizing Enzymes from Arthrobacter globiformis A19
- Enzymatic Synthesis of Glycosyl Cyclic Tetrasaccharide with 6-α-Glucosyltransferase and 3-α-Isomaltosyltransferase(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Cloning and Sequencing of Kojibiose Phosphorylase Gene from Thermoanaerobacter brockii ATCC35047(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Synthesis of 3-O-β-N-Acetylglucosaminyl Cyclic Tetrasaccharide through a Lysozyme-catalyzed Transfer Reaction(Biochemistry & Molecular Biology)
- Transglycosylation of Glycosyl Residues to Cyclic Tetrasaccharide by Bacillus stearothermophilus Cyclomaltodextrin Glucanotransferase Using Cyclomaltodextrin as the Glycosyl Donor(Biochemistry & Molecular Biology)
- Production of Cyclic Tetrasaccharide from Starch Using a Novel Enzyme System from Bacillus glob isporus C11
- Genetic Identification of Members of the Genus Corynebacterium at Genus and Species Levels with 16S rDNA-Targeted Probes
- Mutation of the Yeast ε-COP Gene ANU2 Causes Abnormal Nuclear Morphology and Defects in Intracellular Vesicular Transport
- Saccharomyces cerevisiae KAR2 (BiP) Gene Expression Is Induced by Loss of Cytosolic HSP70/Ssa1p through a Heat Shock Element-Mediated Pathway^1
- Thermosensitivity of Green Fluorescent Protein Fluorescence Utilized to Reveal Novel Nuclear-Like Compartments in a Mutant Nucleoporin NSP1
- Amplification of rfbE and fliC Genes by Polymerase Chain Reaction for Identification and Detection of Salmonella Serovar Enteritidis, Dublin and Gallinarum-Pullorum
- Carbohydrate Structures of the Glycoprotein Allergen Cry j I from Japanese Cedar (Cryptomeria japonica) Pollen
- Enzymatic Properties of Recombinant Kojibiose Phosphorylase from Caldicellulosiruptor saccharolyticus ATCC43494
- Inhibitory Effects of 2-Amino-3H-phenoxazin-3-one on the Melanogenesis of Murine B16 Melanoma Cell Line
- Purification and Characterization of Glucosyltransferase and Glucanotransferase Involved in the Production of Cyclic Tetrasaccharide in Bacillus globisporus C11(Biochemistry & Molecular Biology)
- Cloning and Sequencing of the Genes Encoding Cyclic Tetrasaccharidesynthesizing Enzymes from Bacillus globisporus C11(Biochemistry & Molecular Biology)
- Cloning and Sequencing of the β-Fructofuranosidase gene from Bacillus sp.
- Trehalose-producing Operon treYZ from Arthrobacter ramosus S34
- Purification and Characterization of Cyclic Maltosyl-(1→6)-Maltose Hydrolase and α-Glucosidase from an Arthrobacter globiformis Strain
- Lactosucrose Inhibits Body Fat Accumulation in Rats by Decreasing Intestinal Lipid Absorption
- Effects of Dietary Lactosucrose (4^G-β-D-galactosylsucrose) on the IgE Response in Mice
- 20aWD-5 粘性流による粒状体中の水路網形成とDDSへの応用(流体物理(複雑流体・物体まわりの流れ・安全性など),領域11,統計力学,物性基礎論,応用数学,力学,流体物理)
- 21aRE-9 同心二重円筒内の粘性流による砂漣形成(領域12,領域11合同 非平衡現象II(粉体・流体・界面),領域12,ソフトマター物理,化学物理,生物物理)
- 粘性流による粒状体中の空洞の崩壊とDDS(Drug Delivery System) への応用(複雑流体の数理とシミュレーション)
- 渦輪の粒状体平面への衝突(複雑流体の数理とシミュレーション)
- 同心二重円筒内の定常粘性流による砂漣形成(複雑流体の数理とシミュレーション)
- 鉛直振動する粒状体薄層の曲げ波とさざ波 : 固液相転移(複雑流体の数理とその応用)
- 単一出口における粒状体の流れやすさの研究(複雑流体の数理とその応用)
- 鉛直加振した2次元粉粒体粒子の挙動 (複雑流体の構造形成と崩壊の数理)
- 渦輪の粉粒体表面への衝突 (複雑流体の構造形成と崩壊の数理)
- 同心二重円筒内の定常流による砂漣の形成 (複雑流体の構造形成と崩壊の数理)
- 粒状体中の空洞の流れによる崩壊過程 (複雑流体の構造形成と崩壊の数理)
- 22pWD-5 粒状体中の空洞の流れによる崩壊実験
- 流れによる粒状体中の空洞領域の成長 (複雑流体の数理III)
- 学生の思考方法に着目したSAIL「自由課題実験」の新しい指導方針(教育実践)
- 23aWF-5 クント管における粒状体の縞状パターン
- Cloning, Sequencing and Expression of the Genes Encoding Cyclic α-Maltosyl-(1→6)-maltose Hydrolase and α-Glucosidase from an Arthrobacter globiformis Strain
- Fundamental Process of the Self-Organization of Waterway Network in Granular Material (複雑流体の数理2)
- Enzymatic Properties of Recombinant Kojibiose Phosphorylase from Caldicellulosiruptor saccharolyticus ATCC43494
- Preventive Effect of Coriandrum sativum (Chinese Parsley) on Aluminum Deposition in ICR Mice
- Isolation and Identification of Anti-Helicobacter pylori Compounds from Polygonum tinctorium Lour.
- Anti-Helicobacter pylori Compounds in Brazilian Propolis
- Purification and Characterization of Highly Branched α-Glucan–Producing Enzymes from Paenibacillus sp. PP710
- Purification and Characterization of Highly Branched α-Glucan-Producing Enzymes from Paenibacillus sp. PP710