Royal Jelly Inhibits the Production of Proinflammatory Cytokines by Activated Macrophages
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概要
- 論文の詳細を見る
In this study, we have examined the anti-inflammatory actions of royal jelly (RJ) at a cytokine level. When supernatants of RJ suspensions were added to a culture of mouse peritoneal macrophages stimulated with lipopolysaccharide and IFN-γ, the production of proinflammatory cytokines, such as TNF-α, IL-6, and IL-1, was efficiently inhibited in a dose-dependent manner without having cytotoxic effects on macrophages. This suggests that RJ contains factor(s) responsible for the suppression of proinflammatory cytokine secretion. We named the factor for honeybees RJ-derived anti-inflammatory factor (HBRJ-AIF), and further investigated the molecular aspects of it. Size fractionation study showed that HBRJ-AIF is composed of substances of low (<5 kDa) and high (>30 kDa) molecular weights, with the former being a major component. Chromatographic analysis showed that MRJP3 is one candidate for the HBRJ-AIF with high molecular weights. Thus, our results suggest that RJ has anti-inflammatory actions through inhibiting proinflammatory cytokine production by activated macrophages.
- 社団法人 日本農芸化学会の論文
- 2004-01-23
著者
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Kohno K
Graduate School Of Biological Sciences Nara Institute Of Science And Technology (naist)
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KOHNO Keizo
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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IWAKI Kanso
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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Ikeda M
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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IWAKI Kanso
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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IKEDA Masao
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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KURIMOTO Masashi
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Iwaki Kanso
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Kibata Masayoshi
Hayashibara Biochemical Laboratories Inc.
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Kurimoto Masashi
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Okamoto I
Showa Pharmaceutical University
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Okamoto Iwao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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KOHNO Keizo
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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SANO Osamu
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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ARAI Norie
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.
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ARAI Norie
Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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佐野 理
東京農工大
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Kohno Keizo
Biomedical Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Kubota Michio
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Kubota M
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Kurimoto M
Fujisaki Institute Hayashibam Biochemical Laboratories Inc.
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Maruta K
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Ikeda Masao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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