Iron(III)Picolinate-Induced Oxygenation and Subsequent Rearrangement of Triterpenoid Derivatives with Hydrogen Peroxide
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概要
- 論文の詳細を見る
The reaction of oleanane triterpenoid 1b with a Fe^<III>(PA; picolinate)_3/H_2O_2/MeCN system (reagent system A), a simple model system for mono-oxygenase, gave the 11α-hydroxyl derivative 3 as major product, along with 11-oxo derivative 4 and 12-oxo derivative 6. The reaction of lupane triterpenoid 2b with reagent system A gave only oxidative rearrangement compounds, (20R)-aldehyde 8 and (20S)-aldehyde 9 were epimeric isomers. Then, we have found that iron(III) picolinate complex, Fe^<III>(PA)_3 is efficient in effecting the rearrangement of triterpenoid epoxides 5 and 7 into the corresponding cargonyl compounds, 6,8 and 9 with 1,2-shift of the hydride.
- 公益社団法人日本薬学会の論文
- 2000-01-01
著者
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Okamoto I
Showa Pharmaceutical University
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Okamoto Iwao
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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TAKEYA Tetsuya
Showa College of Pharmaceutical Sciences
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KOTANI Eiichi
Showa Pharmaceutical University
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Takeya T
Showa Pharmaceutical University
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Kotani E
Showa Pharmaceutical University
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Kotani Eiichi
Showa College Of Pharmaceutical Sciences
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Okamoto Iwao
Showa Pharmaceutical University
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KAGAWA Yoshiki
Showa College of Pharmaceutical Sciences
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