Oxygenation Reaction of Methyl Valproate with A Mono-oxygenase Model Reagent : Implication for Stereochemical Identification of the Mammalian Metabolites of Valproic Acid
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概要
- 論文の詳細を見る
Non-enzymic oxygenation reaction of methyl valproate (2) utilizing a simple model system for mono-oxygenases, Fe(MeCN)^<2+>_6-H_2O_2-Ac_2O in MeCN, was investigated in connection with stereochemical analyses of the mammalian metabolites of 1. This oxygenation reaction of methyl valproate (2) gave a 92 : 8 mixture of the anti-isomer 4a and the syn-isomer 4b, together with 5a, and 5b corresponding to the mammalian metabolites of 1. The stereochemistry of 4a, 5a, and 5b was elucidated by spectral analyses of the corresponding β-lactone 6a, γ-lectone 7a and 7b prepared from the oxygenation products. The asymmetric synthesis of (+)-7a was also achieved.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
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TAKEYA Tetsuya
Showa College of Pharmaceutical Sciences
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TOBINAGA Seisho
Showa College of Pharmaceutical Sciences
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KOTANI Eiichi
Showa Pharmaceutical University
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Kotani Eiichi
Showa College Of Pharmaceutical Sciences
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TAKEYA Tetsuta
Showa College of Pharmaceutical Sciences
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YOSHIIKE Motohide
Showa College of Pharmaceutical Sciences
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WATANABE Atsuko
Showa College of Pharmaceutical Sciences
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