A New Concise Synthesis of Arcyriacyanin A and Its Unique Inhibitory Activity against a Panel of Human Cancer Cell Line
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概要
- 論文の詳細を見る
The nucleophilic addition reaction of N-tosyl-4-oxo-4,5,6,7-tetrahydroindole (12) with the lithium salt of 1-methoxyindole (5), followed by dehydration with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) gave the derivative of 2,4'-bi-1H-indole (9) which provides a new concise synthetic method of an indole pigment of the slime mould, arcyriacyanin A. The compound was first demonstrated here to have unique inhibitory activity to a panel of human cancer cell lines and to inhibit protein kinase C and protein tyrosine kinase.
- 公益社団法人日本薬学会の論文
- 2000-01-01
著者
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Watanabe K
School Of Life Science Tokyo University Of Pharmacy And Life Science
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Yoshida Takuji
Showa Pharmaceutical University
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Yoshida Takuji
Showa College Of Pharmaceutical Sciences
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TOBINAGA Seisho
Showa College of Pharmaceutical Sciences
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MURASE Masayuki
Showa Pharmaceutical University
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Murase M
Showa Pharmaceutical University
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Murase Masayuki
Showa College Of Pharmaceutical Sciences
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WATANABE Kazuhiro
Showa College of Pharmaceutical Sciences
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Tobinaga S
Showa Pharmaceutical University
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Murase M
Showa College Of Pharmaceutical Sciences
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Watanabe Kazuki
Faculty Of Pharmaceutical Sciences Aomori University
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