New Steroidal Glycosides from Rhizomes of Clintonia udensis
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概要
- 論文の詳細を見る
A total of 10 steroidal glycosides, together with three new spirostanol glycosides (6–8), a new furostanol glycoside (9), and a new cholestane glycoside (10), were isolated from the rhizomes of Clintonia udensis (Liliaceae). The structures of the new compounds were determined on the basis of extensive spectroscopic analyses, including 2-D nuclear magnetic resonance (NMR) data, and of hydrolytic cleavage followed by chromatographic or spectroscopic analyses. The isolated glycosides were evaluated for their cytotoxic activity against HL-60 leukemia cells. Spirostanol glycosides 1 and 2, and furostanol glycoside 4 showed cytotoxic activity with IC50 values of 3.2±0.02, 2.2±0.12, and 2.2±0.06 μg/ml, respectively. Neither the spirostanol and furostanol saponins with a hydroxy group at C-1 (6 and 9) and C-12 (7 and 8) nor cholestane glycosides (5 and 10) exhibited apparent cytotoxic activity at a sample concentration of 10 μg/ml.
- 社団法人 日本農芸化学会の論文
著者
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Watanabe K
School Of Life Science Tokyo University Of Pharmacy And Life Science
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三巻 祥浩
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Mimaki Yoshihiro
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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Watanabe Kazuki
Faculty of Pharmaceutical Sciences, Aomori University
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MATSUO Yukiko
Tokyo University of Pharmacy and Life Sciences, School of Pharmacy
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