Total Synthesis of Dictamnol, a Trinor-Guaiane Type Sesquiterpene from the Roots of Dictamnus dasycarpus TURCZ.
スポンサーリンク
概要
- 論文の詳細を見る
Dictamnol (1), a trinor-guaiane type seequiterpene from the roots of Dictamnus dasycarpus TURCZ., was synthesized from 4α-acetoxy-3,4,4a, 5,6,8aβ-hexahydro-4aα-methyl-2H, 8H-naphthalene-1,7-dione (3) by the utilization of an intramolecular base-induced rearrangement with sodium tert-amylate as a key step (27→28). Compound 3 was prepared from a chiral dione, (S)3,4,8,8a-tetrahydro-8aα-methyl-2H, 7H-naphthalene-1,6-dione (2) according to the procedure of de Groot et al. [J. Org. Chem., 48,4380 (1983)] and was transformed into dictamnol (1) via 22,23,24,26,27,28,and 30. Thus, the absolute configuration of dictamnol is as represented by formula 1.
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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KATO Yasuyo
Kyoto Pharmaceutical University
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Takeuchi Naoki
Showa Pharmaceutical University
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Takeuchi Naoki
Showa College Of Pharmaceutical Sciences
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Koike Tohru
Dep. Of Functional Molecular Sci. Graduate School Of Biomedical Sciences Hiroshima Univ. Kasumi 1-2-
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YASHIRO Kenichi
Kyoto Pharmaceutical University
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Takeuchi N
Showa Pharmaceutical University
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TOBINAGA Seisho
Showa College of Pharmaceutical Sciences
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KOIKE Takeshi
Showa Pharmaceutical University
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YAMAZAKI Katsuya
Showa College of Pharmaceutical Sciences
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Takeuchi N
Meijo Univ. Nagoya Jpn
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FUKUMOTO Naoko
Showa College of Pharmaceutical Sciences
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YASHIRO Kayoko
Showa College of Pharmaceutical Sciences
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Tobinaga S
Showa Pharmaceutical University
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