Syntheses and Anti-histaminic and Anti-allergic Activities of Hexahydro-4-hydroxy-1-benzofuran-2-ones

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概要

• 論文の詳細を見る

• The hexahydro-4-hydroxy-1-benzofuran-2-ones 3a, 4a, and 5a (related to the 6β-hydroxyeremophilenolides 1 and 2,which show anti-histaminic and anti-allergic activities) were synthesized from dimedone through the compounds 18a, 23a, and 24a, followed by dehydration reactions. Pharmacological investigations of 3a, 4a, 5a, 18a, 23a, and 24a showed that compounds 4a and 5a have anti-histaminic activity and cause marked inhibition in the Schultz-Dale reaction.

• 公益社団法人日本薬学会の論文
• 1984-06-25

著者

• 竹内 直樹

  Showa College Of Pharmaceutical Sciences

• 清水 和枝

  Showa College Of Pharmaceutical Sciences

• 飛永 精照

  Showa College of Pharmaceutical Sciences

• 笠間 俊男

  Research Laboratory of Biological Sciences, Kodama Ltd.

• 池田 里香

  Showa College of Pharmaceutical Sciences

• 畠山 久美子

  Showa College of Pharmaceutical Sciences

• 会田 陽子

  Research Laboratory of Biological Sciences, Kodama Ltd.

• 金子 洋子

  Research Laboratory of Biological Sciences, Kodama Ltd.

• 笠間 俊男

  Japan And Research Laboratory Of Biological Sciences Kodama Ltd.

• 会田 陽子

  Japan And Research Laboratory Of Biological Sciences Kodama Ltd.

• Takeuchi N

  Meijo Univ. Nagoya Jpn

• Tobinaga S

  Showa Pharmaceutical University

• 笠間 俊男

  Research Laboratory Of Biological Science Kodama Ltd.

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