THE ANTAGONIST EFFECTS OF COMPOUNDS DERIVED FROM KHELLACTONE ON PLATELET-ACTIVATING FACTOR

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概要

• 論文の詳細を見る

• Crude coumarin constituents of <Peucedanum>___- <praeruptorum>___- Duun.including praeruptorin A (= Pd-Ia) (2) and B (= Pd-II) (11) had an antagonistic effect on a specific platelet activating factor (PAF) in the platelet aggregation induced by several aggregating agents. This provides a new class of PAF antagonists. Studies of the structure-activity relationship with khellactone (1)derivatives and PAF antagonistiic activity indicate that the <cisisomers>___- of 1 at the C-3' and C-4' positions are more favorable than <trans>___- isomers, and the acyl moiety at the C-3' position of 1 requires an appropriate molecular size.

• 公益社団法人日本薬学会の論文
• 1988-10-25

著者

• 竹内 直樹

  Showa College Of Pharmaceutical Sciences

• Takeuchi N

  Showa College Of Pharmaceutical Sciences

• 大野 隆行

  Showa College Of Pharmaceutical Sciences

• 笠間 俊男

  Reseearch Laboratory of Biological Science, Kodama Ltd.,

• 黛 清

  Reseearch Laboratory of Biological Science, Kodama Ltd.,

• 田丸 健次

  Reseearch Laboratory of Biological Science, Kodama Ltd.,

• 深谷 公昭

  Reseearch Laboratory of Biological Science, Kodama Ltd.,

• 飛永 清照

  Showa College of Pharmaceutical Sciences

• 飛永 精照

  昭和薬科大学

• 黛 清

  Research Laboratories Of Biological Science Kodama Limited

• 笠間 俊男

  Japan And Research Laboratory Of Biological Sciences Kodama Ltd.

• 深谷 公昭

  Research Laboratory of Biological Sciences, Kodama Co., Ltd.,

• 黛 清

  Research Laboratory Of Biological Sciences Kodama Co. Ltd.

• 深谷 公昭

  Research Laboratory Of Biological Sciences Kodama Co. Ltd.

• 田丸 健次

  Reseearch Laboratory Of Biological Science Kodama Ltd.

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