OXYGENATION OF METHYL CYCLOHEXYLPHENYLGLYCOLATE, A CONSTITUTIONAL UNIT OF DRUGS, CATALYSED BY IRON(II) ACETONITRILE SOLVATE

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概要

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• Oxygenation of methyl O-acetyl-α-cyclohexyl-α-phenylglycolate (4c) with the reagent system Fe(MeCN)^<2+>_6-H_2O_2-Ac_2O, a model enzyme system for mono-oxygenase, was investigated in connection with the metabolism of the drug oxybutynin hydrochloride (1) in humans and dogs. Among the oxygenation products 5d, 7,8,and 9,5d, 7,and 8 correspond to the mammalian metabolites of 1 except for the stereo-chemistry in 7 and 8. This suggests implications regarding the mechanism of the mammalian metabolism of the drug.

• 公益社団法人日本薬学会の論文
• 1988-05-25

著者

• 小谷 栄一

  Showa College of Pharmaceutical Sciences

• 間中 明彦

  Research Laboratories Of Biological Science Kodama Ltd.

• 笠間 俊男

  Research Laboratory of Biological Sciences, Kodama Ltd.

• 小谷 榮一

  昭和薬科大学

• 飛永 精照

  昭和薬科大学

• 門田 隆二

  Research Laboratory of Biological Science, Kodama Ltd.,

• 小谷 栄一

  Japan and Showa college of Pharmaceutical Sciences

• 飛永 精照

  Japan and Showa college of Pharmaceutical Sciences

• 笠間 俊男

  Research Laboratory Of Biological Science Kodama Ltd.

• 門田 隆二

  Research Laboratory Of Biological Science Kodama Ltd.

• 小谷 栄一

  昭和薬科大学

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