NON-ENZYMIC AND ENZYMIC OXYGENATIONS OF A DIBENZOCYCLOOCTADIENE LIGNAN, (±)-DEOXYSCHIZANDRIN : IMPLICATIONS FOR BIOSYNTHESIS OF THE CORRESPONDING LIGNANS
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概要
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Non-enzimic and enzymic oxygenation reactions of (±)-dibenzocyclooctadiene lignan, (±)-deoxyschizandrin (1) using a simple model system for mono-oxygenases Fe(MeCN)_6^<2+>-Ac_2O-H_2O_2 and rat liver S9 mix were investigated in connection with mammalian and plant metabolisms of the corresponding lignans. The non-enzymic reaction of 1 gave the two phenol acetates 4a and 5a and a quinone 6,and the enzymic reaction of 1 afforded several compounds from which three compounds characterized as 7,8,and 9 were isolated. The latter result has implications for biosynthesis of these lignans.
- 公益社団法人日本薬学会の論文
- 1994-08-15
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