Pharmacological Activities of the Prenylcoumarins, Developed from Folk Usage as a Medicine of Peucedanum japonicum THUNB.
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概要
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In connection with the chemical structure of coumarin 1 (a mixture of acetylangeloylkhellactone and acetyltigloylkhellactone), a compound isolated from Peucedonum japonicum THUNB., we synthesized eight coumarin compounds (3-10) and performed pharmacological studies on these nince compounds, as well as on another coumarin, praeruptorin A (=Pd-Ia) (2), a compound isolated from Peucedaum praeruptorum DUNN. We studied the effects of compounds 1-5 on isolated smooth muscle and of compounds 1-10 on the cardiovascular system. These compounds showed dose-related antagonistic effects on histamine- and Ca^<2+>-induced contractions in smooth muscle and the potencies were in the order 2>1>seselin (3)>xanthyletin (4)=2,2,0-trimethyl-2H, 8H-benzo[1,2-b : 3,4-b']dipyran-8-one (5). All the compounds except 7-geranyloxy-4-methylcoumarin (10) produced a dose-related increase in vertebral, carotid and femoral blood flow. Compounds 1,5,and 4-methyl-7-(3-methyl-2-butenyloxy)coumarin (8) caused an increase in blood pressure, but 3 and 4 caused a slight decrease. Compounds 2,3,4,5,and 8 increased heart rate. Jatamansinone (6) and jatamansinol (7) caused only slight changes in blood pressure. All the compounds except 10 increased heart rate. Compound 1 also increased blood flow in teh cerebral cortex. Thus, compound 1 was confirmed to have an inhibitory effect on contraction in isolated smooth muscle and an action increasing arterial blood flow. Among the compounds tested in this study, 3,as well as 6 and 7 synthesized on the basis of 3,showed actions similar to those of Ca^<2+> blockers and some compounds had papaverine-like activities. These results suggest that the chemical moiety of compound 3 may be the basis for the pharmacological activities of Peucedanum Japonicum THUNB.
- 公益社団法人日本薬学会の論文
- 1991-06-25
著者
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竹内 直樹
Showa College Of Pharmaceutical Sciences
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飛永 精照
Showa College of Pharmaceutical Sciences
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Takeuchi N
Showa Pharmaceutical University
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笠間 俊男
Research Laboratory of Biological Sciences, Kodama Ltd.
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会田 陽子
Research Laboratory of Biological Sciences, Kodama Ltd.
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笠間 俊男
Japan And Research Laboratory Of Biological Sciences Kodama Ltd.
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会田 陽子
Japan And Research Laboratory Of Biological Sciences Kodama Ltd.
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大木 淳司
Showa College of Pharmaceutical Sciences
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丸山 いずみ
Showa College of Pharmaceutical Sciences
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渡辺 潔
Research laboratory of Biological Sciences, Kodama Ltd.
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Takeuchi N
Meijo Univ. Nagoya Jpn
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Tobinaga S
Showa Pharmaceutical University
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笠間 俊男
Research Laboratory Of Biological Science Kodama Ltd.
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渡辺 潔
Research Laboratory Of Biological Sciences Kodama Ltd.
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