Phosphoproteome Analysis of Hereditary Cataractous Rat Lens α-Crystallin(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
We reported previously that C-terminal truncated α-crystallins were found in lenses of hereditary cataractous rat ICR/f. In this study, we examined the phosphorylation of the crystalline lens proteins, αB-crystallin and αA-crystallin, in cataractous and normal rats of different ages and have found an increase in the phosphorylation of serine residues of truncated α-crystallin in cataractous lens. Phosphorylation and C-terminal truncation of α-crystallins could, both, reduce their chaperone-like activity and lead to cataract formation.
- 公益社団法人日本薬学会の論文
- 2004-12-01
著者
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Takeuchi N
Showa Pharmaceutical University
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TAKEUCHI Noriko
Section of Biochemistry, Faculty of Pharmacy, Meijo University
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KAMEI Akira
Section of Biochemistry, Faculty of Pharmacy, Meijo University
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Nagai Makoto
Faculty Of Pharmaceutical Sciences Hoshi University
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Kamei Akira
Section Of Biochemistry Faculty Of Pharmacy Meijo University
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Kamei A
Meijo Univ. Aichi Jpn
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Kamei A
Meijo Univ. Nagoya Jpn
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Takeuchi N
Meijo Univ. Nagoya Jpn
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TAKAMURA Shinsuke
Section of Biochemistry, Faculty of Pharmacy, Meijo University
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NAGAI Makoto
Section of Biochemistry, Faculty of Pharmacy, Meijo University
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Takeuchi Noriko
Section Of Biochemistry Faculty Of Pharmacy Meijo University
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Takamura Shinsuke
Section Of Biochemistry Faculty Of Pharmacy Meijo University
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