Vasorelaxant Effects of Acer nikoense Extract and Isolated Coumarinolignans on Rat Aortic Rings(Pharmacognosy)

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概要

• 論文の詳細を見る

• The organic extract of the heartwood of Acer nikoense MAXIM. (Aceraceae) showed vasorelaxant activity on rat aorta with or without endothelium. Coumarin [scopoletin (1)] and coumarinolignans [cleomiscosin A (2) and aquillochin (3)] were isolated as major constituents from the organic extract of the heartwood of A. nikoense. Compounds 1-3 exhibited moderate vasorelaxant effects on rat aorta, while 2 and 3 showed vasorelaxant effects in the norepinephrine-stimulated and also in high K^+-depolarized preparations.

• 社団法人日本薬学会の論文
• 2007-06-01

著者

• Itabashi Takeshi

  Faculty of Pharmaceutical Sciences, Hoshi University

• Moriyama Hiroyoshi

  Faculty Of Pharmaceutical Sciences Hoshi University:laboratory Of Pharmacotherapeutics Showa Pharmac

• IIZUKA Toru

  Faculty of Pharmaceutical Sciences, Hoshi University

• NAGUMO Seiji

  Faculty of Pharmaceutical Sciences, Hoshi University

• YOTSUMOTO Hideomi

  Faculty of Pharmaceutical Sciences, Hoshi University

• MORIYAMA Hiroyoshi

  Pharmcotherapeutics Laboratory, Showa Pharmaceutical University

• NAGAI Masahiro

  Ohu University School of Pharmaceutical Sciences

• NAGAI Masahiro

  Faculty of Pharmaceutical Sciences, Hoshi University

• Iizuka Toru

  Laboratory Of Pharmacognosy Yokohama College Of Pharmacy

• Iizuka Toru

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagumo Seiji

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagai M

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagai Masahiro

  Department Of Medicinal Plant Sciences Hoshi University

• Nagai M

  Hoshi Univ. Tokyo Jpn

• Nagai Masahiro

  Faculty Of Pharmaceutical Sciences Hoshi University

• Yotsumoto Hideomi

  Faculty Of Pharmaceutical Sciences Hoshi University

• Ishizaki Takayuki

  Tamagawa University Research Institute

• Nagai Makoto

  Faculty Of Pharmaceutical Sciences Hoshi University

• Itabashi T

  Waseda Univ. Tokyo Jpn

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