Antiplatelet Aggregatory Effects of the Constituents Isolated from the Flower of Carthamus tinctorius
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概要
- 論文の詳細を見る
Four constituents, 6-hydroxykaempferol 3,6,7-tri-O-glucoside (1) 6-hydroxykaempferol 3-O-rutinoside-6-O-glucoside (2), 6-hydroxykaempferol 3,6-di-O-glucoside (3), and syringin (4) were isolated from the flower of Carthamus tinctorius L. and were examined for the inhibitory effects on platelet aggregation. The platelet aggregation was monitored by a platelet aggregometer employing a laser-scattering method. The compounds were identified on the basis of NMR spectral data. Compound 1, 3 and 4 inhibited platelet aggregation induced by collagen. Compound 4 also showed an antiplatelet aggregatory effect when the platelet aggregation was induced by adenosine 5'-diphosphate (ADP). However, 2 showed no inhibitory effect on platelet aggregation induced by collagen or ADP. Furthermore, 1 and 3 showed weak inhibitory effects on the ADP-induced platelet aggregation.
- 日本生薬学会の論文
- 2005-10-20
著者
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Itabashi Takeshi
Faculty of Pharmaceutical Sciences, Hoshi University
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Moriyama Hiroyoshi
Faculty Of Pharmaceutical Sciences Hoshi University:laboratory Of Pharmacotherapeutics Showa Pharmac
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NAGAI Masahiro
Faculty of Pharmaceutical Sciences, Hoshi University
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TANIGUCHI Akemi
Pharmacotherapeutics Laboratory, Showa Pharmaceutical University
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Iizuka Toru
Laboratory Of Pharmacognosy Yokohama College Of Pharmacy
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Iizuka Toru
Faculty Of Pharmaceutical Sciences Hoshi University
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Hoshi K
Laboratory Of Pharmacotherapeutics Showa Pharmaceutical University
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Hoshi Keiko
Department Of Pharmacotherapeutics Showa Pharmaceutical University
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Nagai Masahiro
Department Of Medicinal Plant Sciences Hoshi University
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Nagai M
Hoshi Univ. Tokyo Jpn
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Taniguchi Akemi
Pharmacotherapeutics Laboratory Showa Pharmaceutical University
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Ishizaki Takayuki
Tamagawa University Research Institute
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Hoshi Katsuji
Laboratory Of Pharmacotherapeutics Showa Pharmaceutical University
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Itabashi T
Waseda Univ. Tokyo Jpn
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Iizuka Toru
The Faculty of Pharmaceutical Sciences, Hoshi University
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Nagai Masahiro
The Faculty of Pharmaceutical Sciences, Hoshi University
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