Vasorelaxant Effects of Methyl Brevifolincarboxylate from the Leaves of Phyllanthus niruri(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Methyl brevifolincarboxylate (1) isolated from the leaves of Phyllanthus niruri L. showed a vasorelaxant effect on rat aortic rings. Compound 1 exhibited slow relaxation activity against norepinephrine (NE)-induced contractions of rat aorta with or without endothelium. The compound did not affect contractions induced by a high concentration (60mM) of K^+, whereas it inhibited NE-induced vasocontraction in the presence of nicardipine. These results suggest that the inhibition of NE-induced vasocontraction by compound 1 is in part attributable to a decrease in [Ca^<2+>]_i through receptor-operated Ca^<2+> channels.
- 社団法人日本薬学会の論文
- 2006-01-01
著者
-
Itabashi Takeshi
Faculty of Pharmaceutical Sciences, Hoshi University
-
Moriyama Hiroyoshi
Faculty Of Pharmaceutical Sciences Hoshi University:laboratory Of Pharmacotherapeutics Showa Pharmac
-
IIZUKA Toru
Faculty of Pharmaceutical Sciences, Hoshi University
-
NAGAI Masahiro
Faculty of Pharmaceutical Sciences, Hoshi University
-
Iizuka Toru
Laboratory Of Pharmacognosy Yokohama College Of Pharmacy
-
Iizuka Toru
Faculty Of Pharmaceutical Sciences Hoshi University
-
Nagai M
Faculty Of Pharmaceutical Sciences Hoshi University
-
Nagai Masahiro
Department Of Medicinal Plant Sciences Hoshi University
-
Nagai M
Hoshi Univ. Tokyo Jpn
-
Nagai Masahiro
Faculty Of Pharmaceutical Sciences Hoshi University
-
Ishizaki Takayuki
Tamagawa University Research Institute
-
Nagai Makoto
Faculty Of Pharmaceutical Sciences Hoshi University
-
Itabashi T
Waseda Univ. Tokyo Jpn
-
Nagai Masahiro
Faculty Of Human Environments Studies The University Of Human Environments
-
NAGAI Masahiro
Faculty of Human Environment, University of Human Environments
関連論文
- Novoamauromine and ent-Cycloechinulin: Two New Diketopiperazine Derivatives from Aspergillus novofumigatus
- Post-Translational Modification of βH-Crystallin of Bovine Lens with Aging (Medicina Chemistry)
- Assay-guided Informatory Screening Method for Antiplatelet Effect of Adenosine Isolated from Malbranchea filamentosa IFM 41300 : Inhibitory Behaviors of Adenosine in Different Solvents
- Vasorelaxant Effects of Acer nikoense Extract and Isolated Coumarinolignans on Rat Aortic Rings(Pharmacognosy)
- Inhibitory Effects of Methyl Brevifolincarboxylate Isolated from Phyllanthus niruri L. on Platelet Aggregation(Pharmacognosy)
- Relaxing effects of Phellinus gilvus extract and purified ebricoic acid on rat aortic rings
- Vasorelaxant Effects of Methyl Brevifolincarboxylate from the Leaves of Phyllanthus niruri(Pharmacognosy)
- Antiplatelet Aggregatory Effects of the Constituents Isolated from the Flower of Carthamus tinctorius
- Adenine, an Inhibitor of Platelet Aggregation, from the Leaves of Cassia alata(Pharmacognosy)
- Platelet Aggregatory Effects of Nasturtium officinale and Solanum torvum Extracts
- Antiplatelet Aggregating Activity of Extracts of Indonesian Medicinal Plants I
- A Stabilized Flavonoid Glycoside in Heat-Treated Cassia alata Leaves and Its Structural Elucidation
- Two New Dioxopiperazine Derivatives, Arestrictins A and B, Isolated from Aspergillus restrictus and Aspergillus penicilloides
- The Effectiveness of a Web Bulletin Board Enhanced with a Knowledge Map
- Phylogenetic Relationships between Vorticella convallaria and Other Species Inferred from Small Subunit rRNA Gene Sequences(Taxonomy)
- Studies on the constituents from the fruits of Phaleria macrocarpa
- Anti-tumor Promoting Activities of Isoflavonoids from Wistaria brachybotrys
- Two Novel Diarylheptanoid Glucosides from Myrica gale var. tomentosa and Absolute Structure of Plane-Chiral Galeon
- Zonisamide Increases Dopamine Turnover in the Striatum of Mice and Common Marmosets Treated With MPTP
- Effects of Fukinolic Acid and Cimicifugic Acids from Cimiclfuga Species on Collagenolytic Activity
- Vasoactive Effects of Cimicifugic Acids C and D, and Fukinolic Acid in Cimicifuga Rhizome
- Three New Fukiic Acid Esters, Cimicifugic Acids A, B and C, from Cimicifuga Simplex WORMSK.
- Effect of the Adhesive Layer Thichness on the Fracture Toughness of Dental Adhesive Resins
- Inhibition of LysoPAF Acetyltransferase by the Ingredients from Lithospermum Root
- Inhibition of LysoPAF Acetyltransferase Activity by Components of Licorice Root
- A new indoloditerpene derivative, penijanthine A, isolated from Penicillium janthinellum
- Two New Meroterpenoids, Penisimplicin A and B, Isolated from Penicillium simplicissimum
- Lepidepyrone, a New γ-Pyrone Derivative, from Neolentinus lepideus, Inhibits Hyaluronidase
- Phosphoproteome Analysis of Hereditary Cataractous Rat Lens α-Crystallin(Biochemistry/Molecular Biology)
- In Vitro Study for Inhibition of NO Production about Constituents of Sappan Lignum(Pharmacognosy)
- Phenolic Glycosides from Eupatorium fortunei Turcz
- New penicillide derivatives isolated from Penicillium simplicissimum
- New Vermistatin Derivatives Isolated from Penicillium simplicissimum
- Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice
- Sensitive Spectrophotometric Determination of Phosphate Using Silica-Gel Collectors
- A New Pentanorlanostane Derivative, Cladosporide A, as a Characteristic Antifungal Agent against Aspergillus fumigatus, Isolated form Cladosporium sp.
- A New Nonadride Derivative, Dihydroepiheveadride, as Characteristic Antifungal Agent against Filamentous Fungi, Isolated from Unidentified Fungus IFM 52672
- Isolation and Structures of New Azaphilone Derivatives, Falconensins E-G, from Emericella falconensis and Absolute Configurations of Falconensins A-G
- Structures of new triterpene glycosides, malbrancheosides A-D, from Malbranchea filamentosa
- New citrinin derivatives isolated from Penicillium citrinum
- Bone Resorption Inhibitors from Hop Extract
- Oleanane Acid from Myrica cerifera
- Studies on the Constituents of Aceraceae Plants. XIII. Diarylheptanoids and Other Phenolics from Acer nikoense
- A New Antifungal Macrolide, Eushearilide, Isolated from Eupenicillium shearii
- The Absolute Structures of Dihydroepiheveadride, as Characteristic Antifungal Agent against Filamentous Fungi, and Its Related Compounds from Unidentified Fungus IFM 52672
- A novofumigatamide, new cyclic tripeptide from Aspergillus novofumigatus
- Three New Types of Indoloditerpenes, Emindole PA-PC, from Emericella purpurea. Revision of the Structure of Emindole PA
- Phenolic Glycosides from Eupatorium fortunei Turcz.
- Phenolic Constituents of Cimicifuga Species Rhizomes.
- Antiplatelet Aggregating Activity of Extracts of Indonesian Medicinal Plants I
- Antiplatelet Aggregatory Effects of the Constituents Isolated from the Flower of Carthamus tinctorius
- Platelet Aggregatory Effects of Nasturtium officinale and Solanum torvum Extracts
- Phenolic Constituents of Lycopus lucidus(Natural Medicine Note)
- Inhibition of LysoPAF Acetyltransferase by the Ingredients from Lithospermum Root
- Studies on the Constituents of Aceraceae Plants (X) : Isolation of Flavonoid Glycosides and a Cerebroside from the Leaves of Acer negundo
- Studies on the Constituents of Aceraceae Plants. IX. : Constituents of Acer cissifolium
- A new antifungal yellow pigment from Aspergillus nishimurae
- The cytotoxic and antifungal activities of two new sesquiterpenes, malfilanol A and B, derived from Malbranchea filamentosa
- Seasonal Changes in Water Quality of Rivers and Ground Water in Karakalpakstan, Uzbekistan