Two New Meroterpenoids, Penisimplicin A and B, Isolated from Penicillium simplicissimum

スポンサーリンク

概要

• 論文の詳細を見る

• In the course of our rsearch for new antifungal agents, two new meroterpenoids, penisimplicin A (1) and B (2), were isolated from Penicillium simplicissimum. The absolute structures of 1 and 2 were established by spectroscopic and chemical investigation. Penisimplicin A (1) and B (2) are rare examples of D-ring seco-meroterpenoids. Since compounds 1 and 2 showed no antifungal activities, the isolation of the compounds with antifungal activity will be attempted.

• 公益社団法人日本薬学会の論文
• 2005-09-01

著者

• Hosoe Tomoo

  Faculty of Pharmaceutical Sciences, Hoshi University

• Itabashi Takeshi

  Faculty of Pharmaceutical Sciences, Hoshi University

• Takizawa Kayoko

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• Yaguchi Takashi

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• Okada K

  Nucleo De Pesquisas Em Ciencias Ambientais Universidade Catolica De Pernambuco

• Kawai K

  Hoshi Univ. Tokyo Jpn

• Hosoe Tomoo

  Faculty Of Pharmaceutical Sciences Hoshi University

• De Campos

  Nucleo De Pesquisas Em Ciencias Ambientais Universidade Catolica De Pernambuco

• Nozawa K

  School Of Pharmaceutical Sciences Ohu University

• Nozawa Koohei

  Faculty Of Pharmaceutical Sciences Hoshi University

• Fukushima Kazutaka

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• Iizuka Toru

  Laboratory Of Pharmacognosy Yokohama College Of Pharmacy

• Iizuka Toru

  Faculty Of Pharmaceutical Sciences Hoshi University

• Fukushima K

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Fukushima Kazutaka

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Takizawa Kayoko

  Res. Center For Pathogenic Fungi And Microbial Toxicoses Chiba Univ.

• Takizawa Kayoko

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Kawai Koji

  Basic Research Laboratories Toray Industries Inc.

• Yaguchi Takashi

  Res. Center For Pathogenic Fungi And Microbial Toxicoses Chiba Univ.

• Itabashi Takeshi

  Faculty Of Pharmaceutical Sciences Hoshi University

• Ishizaki Takayuki

  Tamagawa University Research Institute

• Kawai Ken-ichi

  Fac. Of Pharmaceutical Sciences Hoshi Univ.

• OKADA Kaoru

  Nucleo de Pesquisas em Ciencias Ambientais, Universidade Catolica de Pernambuco

• KOMAI Shinichirou

  Faculty of Pharmaceutical Sciences, Hoshi University

• KAWAI Kenichi

  Faculty of Pharmaceutical Sciences, Hoshi University

• Komai Shinichirou

  Faculty Of Pharmaceutical Sciences Hoshi University

• Takizawa K

  Res. Center For Pathogenic Fungi And Microbial Toxicoses Chiba Univ.

• KOMAI Shin-ichirou

  Faculty of Pharmaceutical Sciences, Hoshi University

• Katsuya K

  Graduate School Of Life & Environmental Sciences University Of Tsukuba

• Itabashi T

  Waseda Univ. Tokyo Jpn

• Yaguchi Takashi

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Tomoo Hosoe

  Faculty Of Pharmaceutical Sciences Hoshi University

関連論文

• Novoamauromine and ent-Cycloechinulin: Two New Diketopiperazine Derivatives from Aspergillus novofumigatus
• 35 Emericella heterothallicaの産生する新規エピポリチオジオキソピペラジン誘導体およびその関連化合物(口頭発表の部)
• Isolation and Structures of Antibacterial Binaphtho-α-pyrones, Talaroderxines A and B, from Talaromyces derxii
• STRUCTURE REVISION OF MYCOTOXIN, VIRIDITOXIN, AND ITS DERIVATIVES
• Aspergillus novofumigatus から分離されたジヒドロテレインおよびテレインの血小板凝集作用に関する検討
• マルブランキア・フィラメントサから得られる2種の新規フラノン誘導体
• 好乾性真菌Aspergillus restrictus A17株のアレルゲン活性
• 真菌からの新規生理活性リード化合物の探索(平成18年度共同利用研究報告)
• ブラジル土壌より分離されたアスペルジルス・フミガツスIFM 54246株から得られた抗真菌活性物質
• ネオサルトリア・フィッシェリからのイソテレインの単離
• 05-15 真菌からの生理活性物質の探索(平成17年度共同利用研究報告)
• 研究課題'04-23 真菌からの生理活性物質の探索(平成16年度 共同利用研究報告)
• 120(P-74) 未同定真菌IFM52672からの抗真菌物質の分離と構造決定(ポスター発表の部)
• 468 気管支喘息患者における好乾菌Asperugillus restrictus RAST 陽性率の検討
• 467 好乾菌Aspergillus restrictusの産生するアレルゲン活性検討
• A New Azaphilone, Falconensin H, from Emericella falconensis
• Falconensins A, B, C, and D, New Compounds Related to Azaphilone, from Emericella falconensis
• Structures of New Indoloditerpenes, Possible Biosynthetic Precursors of the Tremorgenic Mycotoxins, Penitrems, from Penicillium crustosum
• Structures of Novel Epipolythiodioxopiperazines, Emethallicins B, C, and D, Potent Inhibitors of Histamine Release, from Emericella heterothallica
• Structure of a Novel Epidithiodioxopiperazine, Emethallicin A, a Potent Inhibitor of Histamine Release, from Emericella heterothallica
• Studies on Fungal Products. XVIII. : Isolation and Structures of a New Fungal Depsidone Related to Nidulin and a New Phthalide from Emericella unguis
• Studies on Fungal Products. XVI. : New Metabolites Related to 3-Methylorsellinate from Aspergillus silvaticus
• Electrochemical Methoxylation of Arylacetates
• Isolation of a New Tremorgenic Indologiterpene, 1'-O-Acetylpaxilline, from Emericella striata and Distribution of Paxilline in Emericella spp.
• 84(PA3-4) Emericella属菌類の生産する新規インドロジテルペン誘導体Emindole類およびその関連化合物(ポスター発表の部)
• A Novel Electrochemical Method of Acetylation of Alcohols by Methyl Acetate(Organic,Chemical)
• Syntheses of Antifungal Isocoumarins. III. Synthesis and Antifungal Activity of 3-Aryl-3,4-dihydro-4-substituted-isocoumarins
• Antifungal Activity of Oosponol, Oospolactone, Phyllodulcin, Hydrangenol, and Some Other Related Compounds
• Assay-guided Informatory Screening Method for Antiplatelet Effect of Adenosine Isolated from Malbranchea filamentosa IFM 41300 : Inhibitory Behaviors of Adenosine in Different Solvents
• Vasorelaxant Effects of Acer nikoense Extract and Isolated Coumarinolignans on Rat Aortic Rings(Pharmacognosy)
• Inhibitory Effects of Methyl Brevifolincarboxylate Isolated from Phyllanthus niruri L. on Platelet Aggregation(Pharmacognosy)
• Relaxing effects of Phellinus gilvus extract and purified ebricoic acid on rat aortic rings
• Vasorelaxant Effects of Methyl Brevifolincarboxylate from the Leaves of Phyllanthus niruri(Pharmacognosy)
• Antiplatelet Aggregatory Effects of the Constituents Isolated from the Flower of Carthamus tinctorius
• Adenine, an Inhibitor of Platelet Aggregation, from the Leaves of Cassia alata(Pharmacognosy)
• Platelet Aggregatory Effects of Nasturtium officinale and Solanum torvum Extracts
• Antiplatelet Aggregating Activity of Extracts of Indonesian Medicinal Plants I
• A Stabilized Flavonoid Glycoside in Heat-Treated Cassia alata Leaves and Its Structural Elucidation
• Histoplasma capsulatum variety duboisii Isolated in Japan from an HIV-infected Ugandan Patient
• Atypical Cryptococcus neoformans Isolate from an HIV-Infected Patient in Brazil
• Isolation of Candida dubliniensis from the Oral Cavity of an HIV-positive Child in Brazil
• Studies on Interactions between Traditional Herbal and Western Medicines.V. Effects of Sho-saiko-to (Xiao-Cai-hu-Tang) on the Pharmacokinetics of Carbamazepine in Rats
• Two New Dioxopiperazine Derivatives, Arestrictins A and B, Isolated from Aspergillus restrictus and Aspergillus penicilloides
• Detection of gp43 and ITS1-5.8S-ITS2 Ribosomal RNA Genes of Paracoccidioides brasiliensis in Paraffin-embedded Tissue
• タラロマイセス・フラブスIFM52668株から得られる新フニコン誘導体
• Phylogenetic Relationships between Vorticella convallaria and Other Species Inferred from Small Subunit rRNA Gene Sequences(Taxonomy)
• Studies on the constituents from the fruits of Phaleria macrocarpa
• アスペルジルス属菌IFM51759株から得られたフラノン及びピラノン誘導体のアスペルジルス・フミガツスに対する抗真菌活性
• Histopathological Examination of in vitro Bone Degeneration Caused by a Black Yeast, Exophiala spinifera
• The First Isolation of Hortaea werneckii from a Household Guinea Pig
• Syntheses of Potential Metabolites of a Potent к-Opioid Receptor Agonist, TRK-820
• Rational Drug Design and Synthesis of a Highly Selective Nonpeptide δ-Opioid Agonist, (4aS^*, 12aR^*)-4a-(3-Hydroxyphenyl)-2-methyl-1,2,3,4,4a, 5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67)
• DISCOVERY OF A STRUCTURALLY NOVEL OPIOID K-AGONIST DERIVED FROM 4,5-EPOXYMORPHINAN
• Glycosides Having Chromophores as Substrates for Sensitive Enzyme Analysis. V. Synthesis of 6'-O-Substituted 2'-7'-Dichlorofluorescein N-Acetyl-β-D-glucosaminides as Substrates for the Rate-Assay of N-Acetyl-β-D-glucosaminidase
• A new indoloditerpene derivative, penijanthine A, isolated from Penicillium janthinellum
• Two New Meroterpenoids, Penisimplicin A and B, Isolated from Penicillium simplicissimum
• Lepidepyrone, a New γ-Pyrone Derivative, from Neolentinus lepideus, Inhibits Hyaluronidase
• New penicillide derivatives isolated from Penicillium simplicissimum
• New Vermistatin Derivatives Isolated from Penicillium simplicissimum
• Characterization and Quantification of Fluoxymesterone Metabolite in Horse Urine by Gas Chromatography/Mass Spectrometry
• Structures of Two New 18,22-Cyclosterols, Emesterones A and B, from Emericella heterothallica
• Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice
• The Epidemiology and Mating Behavior of Arthroderma benhamiae var. erinacei in Household Four-toed Hedgehogs (Atelerix albiventris) in Japan
• A substance inducing teliospore production in wheat leaf rust, Puccinia recondita f. sp. tritici
• A New Pentanorlanostane Derivative, Cladosporide A, as a Characteristic Antifungal Agent against Aspergillus fumigatus, Isolated form Cladosporium sp.
• Two new species of Neosartorya from Amazonian soil, Brazil
• Neosartorya takakii, a new species from soil in Brazil
• Teliospore-inducing activity for wheat leaf rust in the extracts of various host plant leaves infected with telia of rust fungi
• A New Nonadride Derivative, Dihydroepiheveadride, as Characteristic Antifungal Agent against Filamentous Fungi, Isolated from Unidentified Fungus IFM 52672
• New Pentanorlanostane Derivatives, Cladosporide B〜D, as Characteristic Antifungal Agents Against Aspergillus fumigatus, Isolated from Cladosporium sp.
• Tetranorditerpene Lactones, Potent Antifungal Antibiotics for Human Pathogenic Yeasts, from a Unique Species of Oidiodendron
• Structures of a New Type of Indoloditerpene, Petromindole, and a New Asterriquinone Derivative, PM-53,from the Ascostromata of Petromyces muricatus
• Isolation and Structures of Dicyanide Derivatives, Epurpurins A to C, from Emericella purpurea
• Isolation and Structures of New Azaphilone Derivatives, Falconensins E-G, from Emericella falconensis and Absolute Configurations of Falconensins A-G
• Studies on Fungal Products. XIV. : Emestrin B, a New Epitrithiodioxopiperazine, from Emericella striata(Organic,Chemical)
• Structures of new triterpene glycosides, malbrancheosides A-D, from Malbranchea filamentosa
• New citrinin derivatives isolated from Penicillium citrinum
• Synthesis of Novel Succinamide Derivatives Having the 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M_2 Muscarinic Receptor Antagonists. I
• Direct Invasion of Bones by Highly Pathogenic Fungi in an in vitro Model and Its Ecological Significance
• An Isolate of Arthroderma benhamiae with Trichophyton mentagrophytes var. erinacei Anamorph Isolated from a Four-Toed Hedgehog (Atelerix albiventris) in Japan
• A New Antifungal Macrolide, Eushearilide, Isolated from Eupenicillium shearii
• A New Pyrrolidine-2,4-dione Derivative, Vermelhotin, Isolated from Unidentified Fungus IFM 52672
• Molecular typing of Trichophyton tonsurans by PCR-RFLP of the ribosomal DNA nontranscribed spacer region
• The Absolute Structures of Dihydroepiheveadride, as Characteristic Antifungal Agent against Filamentous Fungi, and Its Related Compounds from Unidentified Fungus IFM 52672
• Ubiquinone system, GC contents and cellular fatty acid composition of species of the form-genus Malbranchea and Coccidioides immitis for chemotaxonomic study
• Identification of a rust fungus on Pinus pumila collected in the North Kurils, Russia
• Synthesis and Biological Evaluation of 1,2,3,4-Tetrahydroisoquinoline Derivatives as Potent and Selective M_2 Muscarinic Receptor Antagonists
• Synthesis and Biological Evaluation of Phenylacetyl Derivatives Having Low Central Nervous System Permeability as Potent and Selective M_2 Muscarinic Receptor Antagonists
• Synthesis of Novel Succinamide Derivatives Having a 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M_2 Muscarinic Receptor Antagonists. II
• A novofumigatamide, new cyclic tripeptide from Aspergillus novofumigatus
• Three New Types of Indoloditerpenes, Emindole PA-PC, from Emericella purpurea. Revision of the Structure of Emindole PA
• Fungi on submerged wood in the Koito River, Japan
• Rapid and extensive vacuolation of the budding yeasts Saccharomyces cerevisiae and Candida albicans by amphotericin B
• Pathogenic Races of Phakopsora pachyrhizi on Soybean and Wild Host Plants Collected in Japan
• Antiplatelet Aggregating Activity of Extracts of Indonesian Medicinal Plants I
• Antiplatelet Aggregatory Effects of the Constituents Isolated from the Flower of Carthamus tinctorius
• Platelet Aggregatory Effects of Nasturtium officinale and Solanum torvum Extracts
• Molecular Phylogenetics of Multiple Genes on Aspergillus Section Fumigati Isolated from Clinical Specimens in Japan
• A new antifungal yellow pigment from Aspergillus nishimurae
• The cytotoxic and antifungal activities of two new sesquiterpenes, malfilanol A and B, derived from Malbranchea filamentosa

もっと見る 閉じる

スポンサーリンク